Journal
ACTA PHYSIOLOGICA
Volume 231, Issue 4, Pages -Publisher
WILEY
DOI: 10.1111/apha.13607
Keywords
animal models; contraction; myometrium; parturition; pregnancy; species differences; uterus
Categories
Funding
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [F30 HD097925, R01 HD037831, R01 HD088097, R01 HD096737]
- March of Dimes Foundation [6-FY18-664]
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The review provides a summary of studies on uterine excitation and contractions in mice, rats, guinea pigs, and humans, aiming to help new researchers understand the field and provide assistance in experimental design and result interpretation in rodent models.
Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.
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