Journal
ACS NANO
Volume 15, Issue 2, Pages 2099-2142Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c09382
Keywords
hybrid nanosystem; hybrid nanoparticle; nanomaterials; gene therapy; drug delivery; phototherapy; theranostics; biomolecular sensors; inorganic/organic hybridization; biomedical nanosystems
Categories
Funding
- Peggy and Charles Stephenson Endowed Chair fund
- TSET Scholar fund
- [1R01CA253391-01A1]
- [CA213278]
- [2CA136494]
- [P30 CA225500]
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Inorganic/organic hybrid nanosystems have been increasingly developed for their versatility and efficacy in biomedical applications, including gene therapy, drug delivery, and phototherapy. They can be classified based on their components and architecture, showing potential for diverse utility and innovation in the future.
Inorganic/organic hybrid nanosystems have been increasingly developed for their versatility and efficacy at overcoming obstacles not readily surmounted by nonhybridized counterparts. Currently, hybrid nanosystems are implemented for gene therapy, drug delivery, and phototherapy in addition to tissue regeneration, vaccines, antibacterials, biomolecule detection, imaging probes, and theranostics. Though diverse, these nanosystems can be classified according to foundational inorganic/organic components, accessory moieties, and architecture of hybridization. Within this Review, we begin by providing a historical context for the development of biomedical hybrid nanosystems before describing the properties, synthesis, and characterization of their component building blocks. Afterward, we introduce the architectures of hybridization and highlight recent biomedical nanosystem developments by area of application, emphasizing hybrids of distinctive utility and innovation. Finally, we draw attention to ongoing clinical trials before recapping our discussion of hybrid nanosystems and providing a perspective on the future of the field.
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