Journal
ACS NANO
Volume 14, Issue 12, Pages 16840-16853Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c05610
Keywords
aggregation-induced emission; photodynamic therapy; two-photon fluorescence imaging
Categories
Funding
- Research Grants Council of Hong Kong [C6009-17G]
- Innovation and Technology Commission [ITC-CNERC14SC01]
- National Key Research and Development Program of China [2018YFE0190200, 2018YFA0902600]
- Natural Science Foundation of China [21761142006, 81673039]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH039, 121D11KYSB20170026, XDA16020902]
- Fundamental Research Funds for the Central Universities [lzujbky-2020-51]
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Photodynamic therapy (PDT), a noninvasive therapeutic strategy for cancer treatment, which always suffers from the low reactive oxygen species (ROS) yield of traditional organic dyes. Herein, we present lipid-encapsulated aggregation-induced emission nanoparticles (ME NPs) that have a high quantum yield (23%) and a maximum two-photon absorption (TPA) cross-section of 560 GM irradiated by near-infrared light (800 nm). The AIE NPs can serve as imaging agents for spatiotemporal imaging of tumor tissues with a penetration depth up to 505 mu m on mice melanoma model. Importantly, the AIE NPs can simultaneously generate singlet oxygen (O-1(2)) and highly toxic hydroxyl radicals (center dot OH) upon irradiation with 800 nm irradiation for photodynamic tumor ablation. In addition, the ME NPs can be effectively cleared from the mouse body after the imaging and therapy. This study provides a strategy to develop theranostic agents for cancer image-guided PDT with high brightness, superior photostability, and high biosafety.
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