Journal
ACS NANO
Volume 14, Issue 12, Pages 16973-16983Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c06078
Keywords
carbon dot; photonic nanoagent; aptamer; amyloid self-assembly; Alzheimer's disease
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Funding
- National Research Foundation (NRF) via the Creative Research Initiative Center [NRF-2015R1A3A2066191]
- Basic Science Research Program, Republic of Korea [NRF-2017R1D1A1B03033124]
- National Research Council of Science & Technology (NST), Republic of Korea [C070300] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Extracellular deposition of beta-amyloid (A beta) peptide aggregates is a major characteristic of Alzheimer's disease (AD) brain. Because A beta peptide aggregates aggravate neuropathy and cognitive impairment for AD patients, numerous efforts have been devoted to suppressing A beta self-assembly as a prospective AD treatment option. Here, we report A beta-targeting, red-light-responsive carbon dots (CDs), and their therapeutic functions as a light-powered nanomodulator to spatiotemporally suppress toxic A beta aggregation both in vitro and in vivo. Our aptamer-functionalized carbon dots (Apta@ CDs) showed strong targeting ability toward A beta(42) species. Moreover, red LED irradiation induced Apta@CDs to irreversibly denature A beta peptides, impeding the formation of beta-sheet-rich A beta aggregates and attenuating A beta-associated cytotoxicity. Consequently, Apta@CDs-mediated photomodualtion modality achieved effective suppression of A beta aggregation in vivo, which significantly reduced the A beta burden at the targeted sites in the brain of 5xFAD mice by similar to 40% and similar to 25% according to imaging and ELISA analyses, respectively. Our work demonstrates the therapeutic potential of photomodulating CDs for light-driven suppression against A beta self-assembly and related neurotoxicity.
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