Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 2, Pages 3089-3097Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c16510
Keywords
mussel-inspired chemistry; polymeric coating; antimicrobial material; salt-responsive; antifouling
Funding
- National Natural Science Foundation of China [51673175]
- Natural Science Foundation of Zhejiang Province [LZ20E030004]
- Special Foundation for M. E. of Zhejiang Provincial Education Department [GZ19621250015]
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This study successfully designed and fabricated antimicrobial polymeric coatings with different functions by selectively utilizing specific components, demonstrating long-term antifouling activity, high bactericidal efficiency, and salt-responsive bacterial regeneration performance. These coatings provide reliable and highly efficient antimicrobial surfaces for potential biomedical applications.
Numerous efforts to fabricate antimicrobial surfaces by simple yet universal protocols with high efficiency have attracted considerable interest but proved to be particularly challenging. Herein, we designed and fabricated a series of antimicrobial polymeric coatings with different functions from single to multiple mechanisms by selectively utilizing diethylene glycol diglycidyl ether (PEGDGE), polylysine, and poly[glycidylmethacrylate-co-3-(dimethyl(4-vinylbenzyl)ammonium)propyl sulfonate] (poly(GMA-co-DVBAPS)) via straightforward mussel-inspired codeposition techniques. Bactericidal polylysine endowed the modified surfaces with a high ability (90%) to kill attached bacteria, while PEGDGE components with unique surface hydration prevented bacterial adhesion, avoiding the initial biofilm formation. Moreover, excellent salt-responsive poly(GMA-co-DVBAPS) enabled reactant polymeric coatings to change chain conformations from shrinkable to stretchable state and subsequently release >90% attached bacteria when treated with NaCl solution, even after repeated cycles. Therefore, the obtained polymeric coatings, polydopamine/poly(GMA-co-DVBAPS) (PDA/ PDV), polydopamine/polylysine/poly(GMA-co-DVBAPS) (PDA/L-PDV), and polydopamine/polylysine/poly(GMA-co DVBAPS)/diethylene glycol diglycidyl ether (PDA/L-PDV-PEGDGE), controllably realized functions from single and dual to multiple antimicrobial mechanisms, as evidenced by long-term antifouling activity to bacteria, high bactericidal efficiency, and salt-responsive bacterial regeneration performance with several bacterial killing-release cycles. This study not only contributes to mussel-inspired chemistry for polymeric coatings with controllable functions but also provides a series of reliable and highly efficient antimicrobial surfaces for potential biomedical applications.
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