Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 51, Pages 56830-56838Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c17579
Keywords
rhabdomyolysis; nanozyme; ceria nanoparticles; ROS scavenging acute kidney injury
Funding
- National Natural Science Foundation of China [82071985]
- National Key R&D Program of China [2018YFA0704000]
- Basic Research Program of Shenzhen [JCYJ20180507182413022, JCYJ20170412111100742]
- Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project [2018B030308003]
- Shenzhen Science and Technology Program [KQTD20190929172538530]
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Rhabdomyolysis-induced acute kidney injury (AKI) is closely related to abundant reactive oxygen species (ROS). Owing to the multi-enzymatic activity and broad-spectrum ROS scavenging capacity of ceria nanoparticles (ceria NPs), herein, we report ultrasmall citric acid modified ceria nanozymes (3-4 nm) as antioxidants to alleviate rhabdomyolysis-induced AKI through removing excessive ROS. The as-prepared ceria NPs exhibited multi-enzymatic properties such as peroxidase, catalase, and superoxide dismutase, offering efficient protection of renal cells against H2O2 stimulation in vitro. Moreover, due to their ultrasmall size, ceria NPs could efficiently accumulate in the kidneys, thus protecting renal cells against ROS in vivo. Our results present ultrasmall ceria nanozymes as antioxidants for rhabdomyolysisinduced AKI alleviation, which shows great potential in clinic.
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