Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 1, Pages 312-323Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c21508
Keywords
chloroquine; drug delivery; metal-organic frameworks; SARS-CoV-2; UiO-66
Funding
- Strata Mechanics Research Institute of the Polish Academy of Sciences
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Our study presents a modulated synthesis nanocrystalline defective UiO-66 metal-organic framework as a potential chloroquine diphosphate (CQ) delivery system, showing increased pore volume and enhanced CQ loading. Drug release tests confirmed prolonged CQ release and reduced cardiotoxicity effects in comparison to pure CQ.
In this study, we present a modulated synthesis nanocrystalline defective UiO-66 metal-organic framework as a potential chloroquine diphosphate (CQ) delivery system. Increasing the concentration of hydrochloric acid during the modulated synthesis resulted in a considerable increase of pore volume, which enhanced the CQ loading in CQ@UiO-66 composites. Drug release tests for CQ@UiO-66 composites have confirmed prolonged CQ release in comparison with pure CQ In vivo tests on a Danio reiro model organism have revealed that CQ released from CQ@UiO-66 25% showed lower toxicity and fewer cardiotoxic effects manifested by cardiac malformations and arrhythmia in comparison to analogous doses of CQ. Cytotoxicity tests proved that the CQ loaded on the defective UiO-66 cargo resulted in increased viability of cardiac cells (H9C2) as compared to incubation with pure CQ The experimental results presented here may be a step forward in the context of reducing the cardiotoxicity CQ.
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