Journal
CYTOTHERAPY
Volume 18, Issue 1, Pages 13-24Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2015.10.008
Keywords
cell therapy; exosomes; mesenchymal stromal cells; regeneration; secretome
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Funding
- Manipal University, Manipal, India
- AMET University, Kanathur, Chennai, India
- Taylor's University School of Medicine, Selangor, Malaysia
- NATIONAL CANCER INSTITUTE [R01CA151851] Funding Source: NIH RePORTER
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The unique properties of mesenchymal stromal/stem cells (MSCs) to self-renew and their multipotentiality have rendered them attractive to researchers and clinicians. In addition to the differentiation potential, the broad repertoire of secreted trophic factors (cytokines) exhibiting diverse functions such as immunomodulation, anti-inflammatory activity, angiogenesis and antiapoptotic, commonly referred to as the MSC secretome, has gained immense attention in the past few years. There is enough evidence to show that the one important pathway by which MSCs participate in tissue repair and regeneration is through its secretome. Concurrently, a large body of MSC research has focused on characterization of the MSC secretome; this includes both soluble factors and factors released in extracellular vesicles, for example, exosomes and microvesicles. This review provides an overview of our current understanding of the MSC secretome with respect to their potential clinical applications.
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