A comparison of the collagen triple helix and coiled-coil peptide building blocks on metal ion-mediated supramolecular assembly

Metal ion-mediated assembly of peptides is an intriguing method for developing novel biomaterials. In particular, peptide building blocks based on collagen triple helical and coiled-coil peptides have been functionalized with metal-binding ligands and assemble into hierarchical structures with diverse potential applications. This review outlines the use of metal-mediated assembly with these supramolecular structures and highlights how changes in the building blocks lead to significant differences in structural morphologies, with the identity of the metal-binding ligands and their placement on the building block as crucial aspects in the bottom-up development of the assemblies.

Automated summary

Metal ion-mediated assembly of peptides is a fascinating method for developing novel biomaterials. By functionalizing peptide building blocks with metal-binding ligands, hierarchical structures with diverse potential applications can be achieved. The identity and placement of the metal-binding ligands on the building blocks play crucial roles in the bottom-up development of the assemblies, leading to significant differences in structural morphologies.