Journal
FRONTIERS IN NUTRITION
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2020.00109
Keywords
diabetic foot ulcer; 25-OH-vitamin D; patients with diabetes; vitamin D deficiency; association
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Funding
- National Natural Science Foundation of China [81702140]
- Interdisciplinary Program of Shanghai Jiao Tong University [YG2017QN18]
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Background:Vitamin D deficiency has been associated with an increased risk in several diabetic complications. We aimed to evaluate the association between vitamin D and diabetic foot ulcer (DFU) in patients with type 2 diabetes. Methods:Fifty one patients were included in the study and divided into two groups for study of vitamin D, cholesterol, and triglycerides in blood serum on DFU. The association between vitamin D and DFU was measured by binary logistic regression analysis. The cut point of vitamin D for DFU was assessed by the receiver operating characteristic curve. Results:Levels of 25-OH-vitamin D were lower in patients with DFU than in DM group (P< 0.0001). The AUC of 25-OH-vitamin D was 0.8254 and had an optimal cut point value (13.68 ng/ml) for the identification of DFU, with a sensitivity of 90% and a specificity of 66.67% in all patients. Multivariate logistic regression analysis indicated that the significant risk factors included 25-OH-vitamin D level (P= 0.001, OR = 0.618) and HDL-C level (P= 0.038, OR = 0.012). Conclusion:Low serum 25-OH-vitamin D level was associated with DFU. This indication was more specific than cholesterol and triglycerides levels.
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