Journal
CYTOSKELETON
Volume 73, Issue 10, Pages 551-565Publisher
WILEY
DOI: 10.1002/cm.21294
Keywords
neuron; mRNA translation; eIF2 alpha; neurodegenerative diseases; memory consolidation
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Funding
- FAPESP [2014/15550-9, 2014/04513-5]
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The translation of mRNAs is a tightly controlled process that responds to multiple signaling pathways. In neurons, this control is also exerted locally due to the differential necessity of proteins in axons and dendrites. The phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2) is one of the mechanisms of translational control. The phosphorylation of eIF2 has classically been viewed as a stress response, halting translation initiation. However, in the nervous system this type of regulation has been related to other mechanisms besides stress response, such as behavior, memory consolidation and nervous system development. Additionally, neurodegenerative diseases have a major stress component, thus eIF2 phosphorylation plays a preeminent role and its modulation is currently viewed as a new opportunity for therapeutic interventions. This review consolidates current information regarding eIF2 phosphorylation in neurons and its impact in neurodegenerative diseases. (c) 2016 Wiley Periodicals, Inc.
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