Journal
BIOACTIVE MATERIALS
Volume 5, Issue 3, Pages 721-731Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.04.010
Keywords
Polypeptide; Calcium mineralization; Controlled drug release; pH-responsiveness; Osteosarcoma chemotherapy
Funding
- National Natural Science Foundation of China [51803006]
- Scientific Development Program of Liaoning Province [20170541058]
- China Postdoctoral Science Foundation [2019M650297]
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The acidic microenvironments of tumor tissue and cells provide an opportunity for the development of pH-responsive drug delivery systems in cancer therapy. In this work, we designed a calcium carbonate (CaCO3)-core-cross-linked nanoparticle of methoxy poly(ethylene glycol)-block-poly(L-glutamic acid) through mineralization for intracellular delivery of doxorubicin (DOX), referred to as (NP)-N-Ca/DOX. (NP)-N-Ca/DOX exhibited high drug loading capability, uniform nanoparticle size, and pH-dependent DOX release. In the meantime, the enhanced cell uptake, superior cytotoxicity toward mouse osteosarcoma K7 cells, extended circulation half-life, and improved accumulation of DOX in K7 allograft tumor from (NP)-N-Ca/DOX were also demonstrated. More interestingly, (NP)-N-Ca/DOX displayed improved antitumor effect and reduced side effects against the K7 osteosarcoma-allografted mouse model and the 143B orthotopic osteosarcoma mouse model. Given the superior properties of Ca-mineralized polypeptide nanoparticle for intracellular drug delivery, the smart drug delivery system showed strong competitiveness in clinical chemotherapy of cancers.
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