Journal
NATURE CATALYSIS
Volume 3, Issue 11, Pages 951-958Publisher
NATURE RESEARCH
DOI: 10.1038/s41929-020-00523-8
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Funding
- National Natural Science Foundation of China [21702151, 21871211]
- Fundamental Research Funds for Central Universities [2042019kf0208]
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Enantioselective difunctionalization of alkenes constitutes an efficient strategy to assemble complex chiral molecules from simple racemic or achiral starting materials. Here we present an intermolecular nickel-catalysed enantioselective 1,1-arylboration of unactivated terminal alkenes. The high regio- and enantioselectivities of the reactions arise from a judicious choice of the nickel catalyst rather than the incorporation of a directing group. Moreover, excellent regioselectivities can also be obtained from the reactions of allylbenzenes. We also conducted a series of stereospecific downstream transformations for the enantioenriched secondary boronic esters. These examples represent an efficient catalyst-controlled enantioselective 1,1-difunctionalization of unactivated alkenes.
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