Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 32, Issue -, Pages 63-73Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2016.07.002
Keywords
Internalization; Endocytosis; Trafficking; Endosome; Multivesicular body; Clathrin; Dynamin; Cytokine receptor; TNF; Interleukin; Interferon; Lymphotoxin; Signaling; NF-kappa B; Jak; STAT
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Funding
- Switzerland through Swiss Contribution to the enlarged European Union (Polish-Swiss Research Programme project) [PSPB-094/2010]
- MAESTRO grant from National Science Center [UMO-2011/02/A/NZ3/00149]
- EU FP7 grant FishMed [316125]
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Signaling of plasma membrane receptors can be regulated by endocytosis at different levels, including receptor internalization, endocytic sorting towards degradation or recycling, and using endosomes as mobile signaling platforms. Increasing number of reports underscore the importance of endocytic mechanisms for signaling of cytokine receptors. In this short review we present both consistent and conflicting data regarding endocytosis and its role in signaling of receptors from the tumor necrosis factor receptor superfamily (TNFRSF) and those for interleukins (ILRs) and interferons (IFNRs). These receptors can be internalized through various endocytic routes and most of them are able to activate downstream pathways from endosomal compartments. Moreover, some of the cytokine receptors clearly require endocytosis for proper signal transduction. Still, the data describing internalization mechanisms and fate of cytokine receptors are often fragmentary and barely address the relation between their endocytosis and signaling. In the light of growing knowledge regarding different mechanisms of endocytosis, extending it to the regulation of cytokine receptor signaling may improve our understanding of the complex and pleiotropic functions of these molecules. (C) 2016 The Authors. Published by Elsevier Ltd.
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