Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway

NF-kappa B pathway has long been considered as one of the potent prototypical pro-inflammatory signaling pathway and its role in several aspects of human health has been established. Recent studies have suggested that NF-kappa B activation is the master key in early development and pathobiology of several Cancers. Curcumin is a polyphenolic phytochemical compound with several stablished anti-inflammatory properties and is known to exert its anti-inflammatory effects mostly by interrupting NF-kappa B signaling pathway at multiple stages. Here we tried to provide a summary of recent finding, focusing on introducing NF-kappa B signaling pathways and its potential mechanism involved in development of several types of Cancers. (C) 2015 Elsevier Ltd. All rights reserved.