Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 31, Issue -, Pages 49-59Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2016.06.001
Keywords
Interleukin-15; JAK/STAT; mTOR; Autoimmune diseases
Categories
Funding
- Department of Science and Technology (DST, Govt. of India)
- Department of Biotechnology (DBT, Govt. of India) [BT/PR7857/BRB/10/1215/2013]
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Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic potential. It is predominantly expressed by the myeloid cells, as well as other cell types. IL-15 serves multiple functions including dictating T cell response, regulating tissue repair and B cell homing, modulating inflammation, and activating NK cells. Among cytokines, IL-15 is unique because of its wide expression, tightly regulated secretion, trans-presentation, and therapeutic potential. IL-15 has been investigated for its therapeutic potential for the induction and maintenance of T cell responses. In addition, IL-15 can be targeted by antibody- or mutant IL-15 therapy to reduce inflammation. Its multifaceted biological applications are crucial in immunotherapy. In this article, we review the functions, expression, and regulation of IL-15 for designing an improved IL-15-based therapy targeting the IL-15 signaling pathway. (C) 2016 Elsevier Ltd. All rights reserved.
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