Journal
CYTOKINE
Volume 84, Issue -, Pages 63-73Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2016.05.015
Keywords
Invasive aspergillosis; Fungal virulence; Aspergillus fumigatus; Antifungal effector; Phagocytes
Funding
- NIH [R01 AI093808, R21 AI105617, R01 AI081838]
- NIH/NCI Cancer Center Support Grant [P30 CA008748]
- Dartmouth Lung Biology Center for Molecular, Cellular, and Translational Research Grant [P30 GM106394]
- Center for Molecular, Cellular, and Translational Immunological Research Grant [P30 GM103415]
- Burroughs Wellcome Fund
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Invasive aspergillosis (IA) remains a devastating disease in immune compromised patients despite significant advances in our understanding of fungal virulence and host defense mechanisms. In this review, we summarize important research advances in the fight against IA with particular focus on early events in the interactions between Aspergillus fumigatus and the host that occur in the respiratory tract. Advances in understanding mechanisms of immune effector cell recruitment, antifungal effector mechanisms, and how the dynamic host-fungal interaction alters the local microenvironment to effect outcomes are highlighted. These advances illustrate exciting new therapeutic opportunities, but also emphasize the importance of understanding each unique fungus-host interaction for improving patient outcomes. (C) 2016 Elsevier Ltd. All rights reserved.
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