Journal
CYTOKINE
Volume 77, Issue -, Pages 145-151Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2015.10.017
Keywords
Candida-associated denture stomatitis; Elderly; Monocytes; Cytokines
Funding
- Fundacao de Amparo a Pesquisa do Estado. de Sao Paulo, Brazil - FAPESP [2008/03539-0]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil [135206/2006-5]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil
Ask authors/readers for more resources
Candida-associated denture stomatitis (DS) is the most frequent lesion among denture wearers, especially the elderly. DS is strongly associated with Candida albicans, as well as local and systemic factors, such as impaired immune response. Monocytes are important in the protective immune response against the fungus by the production of cytokines that recruit and activate leukocytes. There are functional changes in these cells with age, and individual alterations involving monocyte response may predispose the host to developing infections by Candida spp. In this study, our aim was to evaluate the production of TNF-alpha, IL-6, CXCL8, IL-1 beta, MCP-1 and IL-10 by monocytes from elderly denture wearers with/without DS and elderly or young non-denture wearers. We detected that monocytes from elderly denture wearers with Candida-related denture stomatitis produced lower levels of CXCL-8, IL-6 and MCP-I. This imbalance in cytokine levels was observed in spontaneous or LPS-stimulated production. Therefore, our data suggested that inherent aspects of the host, such as changes in cytokine production by monocytes, might be associated with the development and the persistence of DS irrespective of aging. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available