Journal
CYTOKINE
Volume 83, Issue -, Pages 189-192Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2016.04.012
Keywords
TNF-alpha; IL-6; Dextran sulfate sodium; MLCK; Claudin-2
Funding
- Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition [14DZ2272400]
- Science and Technology Commission of Shanghai Municipality [14411950400/14411950401]
- Shanghai Municipal Commission of Health and Family Planning [2013ZYJB0017]
- National Natural Science Foundation of China [81400861]
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The cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) have been implicated as important mediators of the inflammatory reaction in patients with intestinal inflammation. The present study was designed to investigate the roles of these cytokines on mucosal barrier function in a mouse model of acute colitis with using anti-cytokine strategies. Mice received 3% dextran sulfate sodium (DSS) in their drinking water for 7 days showed morphological alteration of mucosa and increase of intestinal permeability. Administration of IL-6 monoclonal antibody (mAb) or TNF-alpha mAb significantly attenuated intestinal permeability. IL-6 mAb and TNF-a mAb treatment also effectively suppressed the expression of claudin-2 and myosin light chain kinase (MLCK). Taken together, we indicated that anti-IL-6 and anti-TNF-alpha therapy prevent intestinal permeability induced by intestinal inflammation. (C) 2016 Elsevier Ltd. All rights reserved.
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