Journal
CYTOKINE
Volume 77, Issue -, Pages 238-244Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2015.07.029
Keywords
T-helper 17; IL-17; Glomerulonephritis
Funding
- Division of Rheumatology and Clinical Immunology, UPMC
- Samuel and Emma Winters Foundation
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Different T cell subsets have been implicated in the pathogenesis of glomerulonephritis. Several lines of evidence indicate the recently identified interleukin-17 (IL-17)-producing T cells (Th17 cells) to be involved in the renal inflammatory cascade associated with glomerulonephritis. In this review we outline different forms of glomerulonephritis and the contribution of the Th17/IL-17-axis in mediating the downstream effects and pathology associated with the disease. Learning more about the Th17/IL-17-axis can help to develop promising therapeutic strategy for the treatment of various forms of glomerulonephritis. (C) 2015 Elsevier Ltd. All rights reserved.
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