Journal
CYTOKINE
Volume 83, Issue -, Pages 275-281Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2016.05.013
Keywords
IL-10; Melanogenesis; PI3K/Akt/NF-kappa B signaling pathways; Protective effect
Funding
- National Youth Science Fund Project of China [81503176, 81403030]
- Natural Youth Science Foundation of Jiangsu Province [BK2014124]
- National Undergraduate Training Programs for Innovation and Entrepreneurship [201510295076]
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Vitiligo is a common melanocytopenic disorder of the skin, with acquired focal depigmentation. Normal human skin relies on melanocytes to provide photoprotection and thermoregulation by producing melanin. Interleukin 10 (IL-10) is a pleiotropic immunoregulatory cytokine drawing more and more researchers' attention. The present study was conducted to investigate the effects of IL-10 on melanocytes and elucidate the underlying mechanisms. We proved that IL-10 play no role in regulating melanogenesis of normal human foreskin-derived epidermal melanocytes (NHEM). IL-10 stimulation activated the JAK/Stat-3 and PI3K/Akt signaling pathways. Moreover, IL-10 treatment increased translocation of p65 NF-icB into the nuclear compartment, and up -regulated expression of the pro-survival proteins Bcl-2 and Bcl-xL. IL-10 restored anti-apoptotic proteins expression and suppressed cytochrome c release in H2O2-induced apoptosis. In conclusion, IL-10 may provide pro-survival cues to melanocytes and be applied in the treatment of vitiligo and other depigmenting disorders. (C) 2016 Elsevier Ltd. All rights reserved.
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