Optimization of a Bayesian penalized likelihood algorithm (Q.Clear) for 18F-NaF bone PET/CT images acquired over shorter durations using a custom-designed phantom

Background The Bayesian penalized likelihood (BPL) algorithm Q.Clear (GE Healthcare) allows fully convergent iterative reconstruction that results in better image quality and quantitative accuracy, while limiting image noise. The present study aimed to optimize BPL reconstruction parameters for(18)F-NaF PET/CT images and to determine the feasibility of(18)F-NaF PET/CT image acquisition over shorter durations in clinical practice. Methods A custom-designed thoracic spine phantom consisting of several inserts, soft tissue, normal spine, and metastatic bone tumor, was scanned using a Discovery MI PET/CT scanner (GE Healthcare). The phantom allows optional adjustment of activity distribution, tumor size, and attenuation. We reconstructed PET images using OSEM + PSF + TOF (2 iterations, 17 subsets, and a 4-mm Gaussian filter), BPL + TOF (beta = 200 to 700), and scan durations of 30-120 s. Signal-to-noise ratios (SNR), contrast, and coefficients of variance (CV) as image quality indicators were calculated, whereas the quantitative measures were recovery coefficients (RC) and RC linearity over a range of activity. We retrospectively analyzed images from five persons without bone metastases (male,n= 1; female,n= 4), then standardized uptake values (SUV), CV, and SNR at the 4th, 5th, and 6th thoracic vertebra were calculated in BPL + TOF (beta = 400) images. Results The optimal reconstruction parameter of the BPL was beta = 400 when images were acquired at 120 s/bed. At 90 s/bed, the BPL with a beta value of 400 yielded 24% and 18% higher SNR and contrast, respectively, than OSEM (2 iterations; 120 s acquisitions). The BPL was superior to OSEM in terms of RC and the RC linearity over a range of activity, regardless of scan duration. The SUV(max)were lower in BPL, than in OSEM. The CV and vertebral SNR in BPL were superior to those in OSEM. Conclusions The optimal reconstruction parameters of(18)F-NaF PET/CT images acquired over different durations were determined. The BPL can reduce PET acquisition to 90 s/bed in(18)F-NaF PET/CT imaging. Our results suggest that BPL (beta = 400) on SiPM-based TOF PET/CT scanner maintained high image quality and quantitative accuracy even for shorter acquisition durations.