Journal
ALEXANDRIA ENGINEERING JOURNAL
Volume 60, Issue 1, Pages 859-876Publisher
ELSEVIER
DOI: 10.1016/j.aej.2020.10.015
Keywords
Finite element method; Haematocrit; Intravenous magnetic hyperthermia; Prostate and muscle tumours; Nanoparticle distribution; Two-phase mathematical model
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Funding
- University of the West Indies, Campus Research and Publication Fund [MAR18.18]
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This study investigates a two-phase mathematical model of intravenous magnetic nanoparticle hyperthermia for muscle and prostate tumours. The effects of non-Newtonian nanofluid properties, thermophoresis, and Brownian motion are considered, and numerical solutions are obtained to analyze the impact of tumour size, blood vessel radius, and haematocrit on blood flow and heat transfer.
In the present work, a two-phase mathematical model of intravenous magnetic (Fe3O4, Fe2O3 or FePt) nanoparticle hyperthermia is considered for the treatment of muscle and prostate tumours. The blood-nanoparticle suspension is described as a non-Newtonian (Quemada) nanofluid, and the effects of thermophoresis and Brownian motion are considered. The blood vessel region is surrounded by a cancerous (muscle or prostate) tumour region, a non-cancerous (muscle or prostate) region and a fat layer. Heat is generated within these tissue regions using an external alternating magnetic field. A numerical solution of the problem is obtained using the mixed finite element method with P-2 - P-1 Taylor-Hood elements. Using this numerical solution, the influence of tumour size, blood vessel radius and haematocrit on blood flow, convective heat transfer, nanoparticle mass transport and blood pressure is examined. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of Faculty of Engineering, Alexandria University.
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