Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.00780
Keywords
osseointegration; Hippo-YAP; osteogenesis; angiogenesis; osteoimmunology; bone remodeling; implants
Categories
Funding
- National Natural Science Foundation of China [81701007]
- Sichuan Science and Technology Program [2018RZ0087]
- Fundamental Research Funds for the Central Universities [2018SCUH0006]
- Research Funding for Talents Developing, West China Hospital of Stomatology Sichuan University [RCDWJS2020-6]
- Basic and Applied Basic Research Projects of West China Hospital of Stomatology of Sichuan University [RD-02-201902]
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The social demand for dental implantation is growing at a rapid rate, while dentists are faced with the dilemma of implantation failures associated with unfavorable osseointegration. Clinical-friendly osteogenesis, angiogenesis and osteoimmunology around dental implants play a pivotal role in a desirable osseointegration and it's increasingly appreciated that Hippo-YAP signaling pathway is implicated in those biological processes bothin vitroandin vivoin a variety of study. In this article we review the multiple effects of Hippo-YAP signaling in osseointegration of dental implants by regulating osteogenesis, angiogenesis and osteoimmunology in peri-implant tissue, as well as highlight prospective future directions of relevant investigation.
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