Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 16, Issue 19, Pages 2223-2230Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026616666160216152324
Keywords
Autoimmune diseases; Central nervous system; Inflammation; Metformin; Oxidative stress; Proinflammatory cytokines
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Funding
- University of Lodz [506/1136]
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Autoimmune diseases are characterized by the production of autoantibodies directed against specific organs of own organism. Additional common traits of autoimmune diseases are chronic inflammation due to generation of inflammatory mediators, and disorders of redox processes. The pathogenesis of autoimmune diseases is still unknown. Treatment is based only on relieving the symptoms and improving the quality of patients lives. Metformin, which is used in treatment of type 2 diabetes, has properties which are desirable for autoimmune disease therapy, including anti-inflammatory and antioxidant effects, and the ability to regenerate the endothelium.
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