Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 16, Issue 26, Pages 2963-2994Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026616666160506145539
Keywords
Imidazo[1,2-a] pyridine; SAR; Groebke-Blackburn-Bienayme reaction; Ugi Type; Multicomponent Reaction; N-fused imidazole
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Funding
- MHRD, New Delhi
- Science and Engineering Research Board, Department of Science and Technology (SERB-DST), New Delhi
- DST [CS-361/2011]
- DST-FIST
- Council of Scientific and Industrial Research, New Delhi (India) [02(0202)/14/EMR-II]
- Dr B. R. Ambedkar National Institute of Technology, Jalandhar
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The imidazo[1,2-a] pyridine scaffold is recognized as a privileged structure as it represents a promising area for identification of lead structures towards the discovery of new synthetic drug molecules. Several commercial drugs such as Zolpidem, Olprinone, Soraprazan and many other compounds in biological testing and preclinical evaluation, illustrate the wide therapeutic spectrum in this class of drug scaffolds. The present manuscript represents the assimilation of literature pertaining to medicinal aspects of this pharmacophore including the structure-activity relationships.
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