Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 16, Issue 11, Pages 1262-1289Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026615666150915112334
Keywords
Isatin; Alkaloid; Anticancer agents; Antimicrobial agents; CNS agents; Review
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Funding
- College of Health Science, University of KwaZulu-Natal, Durban
- NRF South Africa
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Isatin as an alkaloidal framework have consistently attracted attention of medicinal chemist towards development of wide range of novel therapeutic agents. This review report has discussed significant isatin lead molecules and their derivatives which have shown promising biological potential in recent times. The substituted isatins showing a potent pharmacological activities such as antimicrobial, antitubercular, anticancer, antioxidant, anti-histaminic, anti-HIV, antiviral, anti-inflammatory, anti-Parkinson's and antidiabetic have been described in this review. The mechanism of action leading to therapeutic activity of the respective isatin derivation has also been recorded. This review reveals that the systematic and rational modifications on isatin motif exhibited significant bio-activities which can be exploited for the development of potent novel therapeutic agents in the future studies. Hence the quest to investigate more structural alterations on isatin scaffold should be continued.
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