Journal
VIROLOGICA SINICA
Volume 35, Issue 6, Pages 673-684Publisher
KEAI PUBLISHING LTD
DOI: 10.1007/s12250-020-00298-z
Keywords
Coronavirus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Genome; Structure; Receptor; Origin
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Funding
- Fundamental Research Funds for the Central Universities [2020kfyXGYJ028]
- National Natural Science Foundation of China [81861138044, 91742114]
- National Science and Technology Major Project [2017ZX10202203]
- Medical Faculty of the University of Duisburg-Essen
- Stiftung Universitaetsmedizin, University Hospital Essen, Germany
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The recent emergence and rapid global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pose an unprecedented medical and socioeconomic crisis, and the disease caused by it, Coronavirus disease 2019 (COVID-19), was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Chinese scientists and physicians rapidly identified the causative pathogen, which turned out to be a novel betacoronavirus with high sequence similarities to bat and pangolin coronaviruses. The scientific community has ignited tremendous efforts to unravel the biological underpinning of SARS-CoV-2, which constitutes the foundation for therapy and vaccine development strategies. Here, we summarize the current state of knowledge on the genome, structure, receptor, and origin of SARS-CoV-2.
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