Journal
PHARMACEUTICS
Volume 12, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics12100931
Keywords
hyaluronic acid; drug conjugates; polymeric nanoparticles; tumor-targeting; targeted-therapy; inflammatory diseases; type 2 diabetes; atherosclerosis
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Funding
- Basic Science Research Programs through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2019R1A2B5B03100464, 2019M3E5D5066525, 2018R1A2B3006080]
- Ministry of Education [2019R1A6A1A11051471]
- National Research Foundation of Korea [2019R1A2B5B03100464] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanoparticles (HA-NPs) have been used widely as target-specific and long-acting nanocarriers for the delivery of a wide range of therapeutic or diagnostic agents. Recently, it has been demonstrated that empty HA-NPs without bearing any therapeutic agent can be used therapeutically for the treatment of inflammatory diseases via modulating inflammatory responses. In this review, we aim to provide an overview of the significant achievements in this field and highlight the potential of HA-NPs for the treatment of inflammatory diseases.
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