Journal
PHARMACEUTICS
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics12080769
Keywords
drug delivery; hybrid formulations; liposomes; biopolymers; fluoroquinolones; multidrug resistance
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES [88887.336865/2019-00]
- National Institute of Science and Technology in Theranostics and Nanobiotechnology -INCT-Teranano (CNPq/CAPES/FAPEMIG) [CNPq-465669/2014-0]
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This work describes the development of a gastroresistant antimicrobial formulation composed of two carriers, pectin and liposomes, intended to improve the efficiency of norfloxacin (NOR) against multi-resistant bacterial strains. The formulations showed physicochemical stability for 180 days (4 degrees C) in terms of size, polydispersity, and zeta potential of the vesicles, prolonging the in vitro release of NOR for 11 h. The hybrid nanocarriers improved the in vitro antimicrobial activity against different multidrug-resistant bacterial strains, such asSalmonellasp.,Pseudomonasaeruginosa,E. coliandCampylobacterjejuni, in comparison to commercial NOR and liposomal suspensions. The in vivo toxicity assay in chicken embryos revealed that the hybrid systems were not toxic in any of the different parameters analyzed, a result also corroborated by the analyses of biochemical biomarkers of the chicken-embryos liver function.
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