Journal
WORLD JOURNAL OF STEM CELLS
Volume 12, Issue 10, Pages 1097-1112Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v12.i10.1097
Keywords
Fertility preservation; Sperm cryopreservation; Spermatogonial stem cell; Testicular organoids; Stem cell; Extracellular vesicles
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With the decline in male fertility in recent years, strategies for male fertility preservation have received increasing attention. In this study, by reviewing current treatments and recent publications, we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation, focusing on the use of spermatogonial stem cells (SSCs), SSC niches, SSC-based testicular organoids, other stem cell types such as mesenchymal stem cells, and stem cell-derived extracellular vesicles. In conclusion, a more comprehensive understanding of the germ cell microenvironment, stem cell-derived extracellular vesicles, and testicular organoids will play an important role in achieving male fertility preservation.
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