Related references
Note: Only part of the references are listed.Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia
Pablo Elias Morande et al.
BLOOD (2019)
Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane
Maria Angela Gomes de Castro et al.
NATURE COMMUNICATIONS (2019)
BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo
Cedric Schleiss et al.
SCIENTIFIC REPORTS (2019)
Constitutive Activation of the B Cell Receptor Underlies Dysfunctional Signaling in Chronic Lymphocytic Leukemia
Carly G. K. Ziegler et al.
CELL REPORTS (2019)
3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
Ana S. Nunes et al.
BIOTECHNOLOGY AND BIOENGINEERING (2019)
TLR Signaling Is Activated in Lymph Node-Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib
Eman L. Dadashian et al.
CANCER RESEARCH (2019)
Outcomes with ibrutinib by line of therapy and post-ibrutinib discontinuation in patients with chronic lymphocytic leukemia: Phase 3 analysis
Susan M. O'Brien et al.
AMERICAN JOURNAL OF HEMATOLOGY (2019)
A multiprotein supercomplex controlling oncogenic signalling in lymphoma
James D. Phelan et al.
NATURE (2018)
Mechanistic Insights into CpG DNA and IL-15 Synergy in Promoting B Cell Chronic Lymphocytic Leukemia Clonal Expansion
Rashmi Gupta et al.
JOURNAL OF IMMUNOLOGY (2018)
Modeling the chronic lymphocytic leukemia microenvironment in vitro
Kyle Crassini et al.
LEUKEMIA & LYMPHOMA (2017)
Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells
Elena Tibaldi et al.
HAEMATOLOGICA (2017)
Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia
E. J. Murphy et al.
LEUKEMIA (2017)
Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood
T. M. Herndon et al.
LEUKEMIA (2017)
Targeting antigen-independent proliferation in chronic lymphocytic leukemia through differential kinase inhibition
E. Slinger et al.
LEUKEMIA (2017)
Delineating the distinct role of AKT in mediating cell survival and proliferation induced by CD154 and IL-4/IL-21 in chronic lymphocytic leukemia
Elinor A. Chapman et al.
ONCOTARGET (2017)
A model integrating tonic and antigen-triggered BCR signals to predict the survival of primary B cells
Shoya Yasuda et al.
SCIENTIFIC REPORTS (2017)
Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells
Elena Tibaldi et al.
HAEMATOLOGICA (2017)
Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens
Nereida Jimenez de Oya et al.
EMBO MOLECULAR MEDICINE (2017)
Leukemia cell proliferation and death in chronic lymphocytic leukemia patients on therapy with the BTK inhibitor ibrutinib
Jan A. Burger et al.
JCI INSIGHT (2017)
Integration of innate into adaptive immune responses in ZAP-70-positive chronic lymphocytic leukemia
Michaela Wagner et al.
BLOOD (2016)
Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells
Anna Parente-Ribes et al.
HAEMATOLOGICA (2016)
Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib
Ailin Guo et al.
ONCOTARGET (2016)
Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells
Anna Parente-Ribes et al.
HAEMATOLOGICA (2016)
Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL
Annalisa D'Avola et al.
BLOOD (2016)
IL-4 enhances expression and function of surface IgM in CLL cells
Maria M. Aguilar-Hernandez et al.
BLOOD (2016)
Mimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation
Ans Rombout et al.
BRITISH JOURNAL OF CANCER (2016)
The APRIL paradox in normal versus malignant B cell biology
M. H. A. van Attekum et al.
CELL DEATH & DISEASE (2016)
Macrophage-mediated chronic lymphocytic leukemia cell survival is independent of APRIL signaling
M. H. A. van Attekum et al.
CELL DEATH DISCOVERY (2016)
Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL
Stefano Iacovelli et al.
BLOOD (2015)
TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells
Patricia K. A. Mongini et al.
JOURNAL OF IMMUNOLOGY (2015)
Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)
Jennifer A. Woyach et al.
BLOOD (2014)
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia
Jennifer R. Brown et al.
BLOOD (2014)
Immunogenetic Studies of Chronic Lymphocytic Leukemia: Revelations and Speculations about Ontogeny and Clinical Evolution
Anna Vardi et al.
CANCER RESEARCH (2014)
The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy
Graham Packham et al.
HAEMATOLOGICA (2014)
B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21
Magdalena Hagn et al.
INTERNATIONAL IMMUNOLOGY (2014)
BTK inhibition targets in vivo CLL proliferation through its effects on B-cell receptor signaling activity
S. Cheng et al.
LEUKEMIA (2014)
Ibrutinib-induced lymphocytosis in patients with chronic lymphocytic leukemia: correlative analyses from a phase II study
S. E. M. Herman et al.
LEUKEMIA (2014)
A novel three-dimensional stromal-based model for in vitro chemotherapy sensitivity testing of leukemia cells
Omar S. Aljitawi et al.
LEUKEMIA & LYMPHOMA (2014)
Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia
J. C. Byrd et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
The Meaning and Relevance of B-Cell Receptor Structure and Function in Chronic Lymphocytic Leukemia
Freda K. Stevenson et al.
SEMINARS IN HEMATOLOGY (2014)
Does B Cell Receptor Signaling in Chronic Lymphocytic Leukaemia Cells Differ from That in Other B Cell Types?
Joseph R. Slupsky
SCIENTIFICA (2014)
IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells
Maria Fernanda Pascutti et al.
BLOOD (2013)
Targeting B-cell anergy in chronic lymphocytic leukemia
Benedetta Apollonio et al.
BLOOD (2013)
Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function
Vania Coelho et al.
BLOOD (2013)
Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells
Carsten Zwick et al.
BLOOD (2013)
Mimicking the microenvironment in chronic lymphocytic leukaemia where does the journey go?
Daniela Asslaber et al.
BRITISH JOURNAL OF HAEMATOLOGY (2013)
Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia
Matthew J. Ahearne et al.
BRITISH JOURNAL OF HAEMATOLOGY (2013)
Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
Dan A. Landau et al.
CELL (2013)
Differential regulation of B-cell proliferation by IL21 in different subsets of chronic lymphocytic leukemia
Ghasem Ghalamfarsa et al.
CYTOKINE (2013)
Biology of Chronic Lymphocytic Leukemia in Different Microenvironments Clinical and Therapeutic Implications
Yair Herishanu et al.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2013)
Clonal expansion in B-CLL: Fungal drivers or self-service?
Mel Greaves
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi
Robbert Hoogeboom et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient
R. Hoogeboom et al.
LEUKEMIA (2013)
B cell receptor signaling in chronic lymphocytic leukemia
Jan A. Burger et al.
TRENDS IN IMMUNOLOGY (2013)
Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia
P. Oppezzo et al.
BLOOD CANCER JOURNAL (2013)
Chronic Lymphocytic Leukemia Cells Are Activated and Proliferate in Response to Specific T Helper Cells
Audun Os et al.
CELL REPORTS (2013)
Immunological aspects in chronic lymphocytic leukemia (CLL) development
Ricardo Garcia-Munoz et al.
ANNALS OF HEMATOLOGY (2012)
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
Sabine Ponader et al.
BLOOD (2012)
Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen
Christoph Steininger et al.
BLOOD (2012)
The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
Martin F. M. de Rooij et al.
BLOOD (2012)
Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice
Laurens P. Kil et al.
BLOOD (2012)
Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells
Emma Hamilton et al.
BRITISH JOURNAL OF HAEMATOLOGY (2012)
Stromal Endothelial Cells Establish a Bidirectional Crosstalk with Chronic Lymphocytic Leukemia Cells through the TNF-Related Factors BAFF, APRIL, and CD40L
Montserrat Cols et al.
JOURNAL OF IMMUNOLOGY (2012)
Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity
E. Kostareli et al.
LEUKEMIA (2012)
Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia
Clive S. Zent et al.
LEUKEMIA & LYMPHOMA (2012)
Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
Marcus Duehren-von Minden et al.
NATURE (2012)
Endogenous antigen tunes the responsiveness of naive B cells but not T cells
Julie Zikherman et al.
NATURE (2012)
Tuning of CD40-CD154 Interactions in Human B-Lymphocyte Activation: A Broad Array of In Vitro Models for a Complex In Vivo Situation
Sonia Neron et al.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2011)
The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia
Yair Herishanu et al.
BLOOD (2011)
Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models
Maria Teresa Sabrina Bertilaccio et al.
BLOOD (2011)
A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
Davide Bagnara et al.
BLOOD (2011)
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
Sarah E. M. Herman et al.
BLOOD (2011)
Cyclin D2 is overexpressed in proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma
Takuro Igawa et al.
CANCER SCIENCE (2011)
Intraclonal Complexity in Chronic Lymphocytic Leukemia: Fractions Enriched in Recently Born/Divided and Older/Quiescent Cells
Carlo Calissano et al.
MOLECULAR MEDICINE (2011)
Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells
Rajendra N. Damle et al.
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2010)
Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells
Xueqing Liang et al.
BLOOD (2010)
Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin
Charles C. Chu et al.
BLOOD (2010)
Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia
Maike Buchner et al.
BLOOD (2010)
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
Sarah E. M. Herman et al.
BLOOD (2010)
Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia
A. Sanchez-Aguilera et al.
LEUKEMIA (2010)
The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia
Michela Tarnani et al.
LEUKEMIA RESEARCH (2010)
Dichotomy in NF-κB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering
J. M. Tromp et al.
ONCOGENE (2010)
Stereotypical Chronic Lymphocytic Leukemia B-Cell Receptors Recognize Survival Promoting Antigens on Stromal Cells
Mascha Binder et al.
PLOS ONE (2010)
CD40/CD40L signaling and its implication in health and disease
Antonios Chatzigeorgiou et al.
BIOFACTORS (2009)
PKCβ is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCβ as a therapeutic target in chronic lymphocytic leukemia
Claudia Holler et al.
BLOOD (2009)
Common community acquired infections and subsequent risk of chronic lymphocytic leukaemia
Lesley A. Anderson et al.
BRITISH JOURNAL OF HAEMATOLOGY (2009)
Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles
M. Plander et al.
LEUKEMIA (2009)
BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgVH unmutated chronic lymphocytic leukemia (CLL) cells
Anna Guarini et al.
BLOOD (2008)
A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
Anna Lanemo Myhrinder et al.
BLOOD (2008)
CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment
Piers E. M. Patten et al.
BLOOD (2008)
Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA
Charles C. Chu et al.
BLOOD (2008)
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy
Marta Muzio et al.
BLOOD (2008)
Reduction of B cell turnover in chronic lymphocytic leukaemia
Julien Defoiche et al.
BRITISH JOURNAL OF HAEMATOLOGY (2008)
In vivo Dynamics of Stable Chronic Lymphocytic Leukemia Inversely Correlate with Somatic Hypermutation Levels and Suggest No Major Leukemic Turnover in Bone Marrow
Rogier van Gent et al.
CANCER RESEARCH (2008)
Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis
Cornelia Hoemig-Hoelzel et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Oxidation
Rosa Catera et al.
MOLECULAR MEDICINE (2008)
ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia
Liguang Chen et al.
BLOOD (2008)
Acquired immune-related and inflammatory conditions and subsequent chronic lymphocytic leukaemia
Ola Landgren et al.
BRITISH JOURNAL OF HAEMATOLOGY (2007)
The effects of CpG ODN on CLL proliferation, apoptosis or phenotype could have an impact on its clinical utility
B. Jahrsdorfer et al.
LEUKEMIA (2007)
Cell proliferation and death: Forgotten features of chronic lymphocytic leukemia B cells
Nicholas Chiorazzi
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2007)
Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
C. Ian Mockridge et al.
BLOOD (2007)
Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
Ola Landgren et al.
BLOOD (2007)
Oncogenic re-wiring of cellular signaling pathways
T. Pawson et al.
ONCOGENE (2007)
The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease
P. G. Longo et al.
LEUKEMIA (2007)
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation
Bernd Jahrsdorfer et al.
BLOOD (2006)
Survival response to B-Cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression
Pierre-Antoine Deglesne et al.
CANCER RESEARCH (2006)
Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells
D de Totero et al.
BLOOD (2006)
The proliferation center microenvironment and prognostic markers in chronic lymphocytic leukemia/small lymphocytic lymphoma
LA Soma et al.
HUMAN PATHOLOGY (2006)
B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia
DJ Allsup et al.
CANCER RESEARCH (2005)
Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells
A Petlickovski et al.
BLOOD (2005)
Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity
M Hervé et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
ZAP-70 directly enhances TgM signaling in chronic lymphocytic leukemia
LG Chen et al.
BLOOD (2005)
B-cell lymphomas differ in their responsiveness to CpG oligodeoxynucleotides
B Jahrsdorfer et al.
CLINICAL CANCER RESEARCH (2005)
Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations
RN Damle et al.
BLOOD (2004)
Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
BT Messmer et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory
MK Chang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
CD40 activation: potential for specific immunotherapy in B-CLL
M von Bergwelt-Baildon et al.
ANNALS OF ONCOLOGY (2004)
Nucleosomes are exposed at the cell surface in apoptosis
M Radic et al.
JOURNAL OF IMMUNOLOGY (2004)
Ligand-independent tonic in B-cell receptor function
JG Monroe
CURRENT OPINION IN IMMUNOLOGY (2004)
Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia
S Lanham et al.
BLOOD (2003)
Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia
LG Chen et al.
BLOOD (2002)
CD5 maintains tolerance in anergic B cells
KL Hippen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells
T Decker et al.
BLOOD (2000)