Related references
Note: Only part of the references are listed.The posttranslational modifications of Hippo-YAP pathway in cancer
Fangjie Yan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2020)
The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models
Betty Y. Tam et al.
CANCER LETTERS (2020)
The YAP1 Signaling Inhibitors, Verteporfin and CA3, Suppress the Mesothelioma Cancer Stem Cell Phenotype
Sivaveera Kandasamy et al.
MOLECULAR CANCER RESEARCH (2020)
First-in-human phase I clinical trial of the NY-ESO-1 protein cancer vaccine with NOD2 and TLR9 stimulants in patients with NY-ESO-1-expressing refractory solid tumors
Mikiya Ishihara et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)
Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer
Ching-Wei Chang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
DKN-01 in combination with pembrolizumab in patients with advanced gastroesophageal adenocarcinoma (GEA): Tumoral DKK1 expression as a predictor of response and survival.
Samuel J. Klempner et al.
JOURNAL OF CLINICAL ONCOLOGY (2020)
Targeting signalling pathways and the immune microenvironment of cancer stem cells - a clinical update
Joseph A. Clara et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2020)
TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects
Gary J. Haderski et al.
PLOS ONE (2020)
The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness
Blanca Felipe-Abrio et al.
CANCERS (2020)
ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype
Benjamin A. Portney et al.
ONCOGENE (2020)
p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs
Hye Yeon Choi et al.
NATURE COMMUNICATIONS (2020)
PAWI-2 overcomes tumor stemness and drug resistance via cell cycle arrest in integrin β3-KRAS-dependent pancreatic cancer stem cells
Jiongjia Cheng et al.
SCIENTIFIC REPORTS (2020)
Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer
Rui Li et al.
CELL DEATH AND DIFFERENTIATION (2019)
TLR4 blockade using TAK-242 suppresses ovarian and breast cancer cells invasion through the inhibition of extracellular matrix degradation and epithelial-mesenchymal transition
Zahra Zandi et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2019)
Verteporfin-Loaded Polymeric Microparticles for Intratumoral Treatment of Brain Cancer
Sagar R. Shah et al.
MOLECULAR PHARMACEUTICS (2019)
Loss of MYBBP1A Induces Cancer Stem Cell Activity in Renal Cancer
Blanca Felipe-Abrio et al.
CANCERS (2019)
Oxidative stress induces senescence in breast cancer stem cells
Guangxian Zhong et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell?
Zahra Ghanbari Movahed et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance
Ladan Mashouri et al.
MOLECULAR CANCER (2019)
Emerging roles and therapeutic value of exosomes in cancer metastasis
Miaowei Wu et al.
MOLECULAR CANCER (2019)
c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer
Blanca Felipe-Abrio et al.
MOLECULAR ONCOLOGY (2019)
U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies
Molly A. Smith et al.
NATURE CELL BIOLOGY (2019)
Role of Toll-Like Receptors in Actuating Stem/Progenitor Cell Repair Mechanisms: Different Functions in Different Cells
Fabio Sallustio et al.
STEM CELLS INTERNATIONAL (2019)
A Role for NF-κB in Organ Specific Cancer and Cancer Stem Cells
Christian Kaltschmidt et al.
CANCERS (2019)
New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools
Sandra Munoz-Galvan et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)
Anti-cancer activity of the novel 2-hydroxydiarylamide derivatives IMD-0354 and KRT1853 through suppression of cancer cell invasion, proliferation, and survival mediated by TMPRSS4
Solbi Kim et al.
SCIENTIFIC REPORTS (2019)
Drugs Targeting Epigenetic Modifications and Plausible Therapeutic Strategies Against Colorectal Cancer
Srinivas Patnaik et al.
FRONTIERS IN PHARMACOLOGY (2019)
Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study
Daniel Morgensztern et al.
CLINICAL CANCER RESEARCH (2019)
European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ)-2019 Update
Marko Babjuk et al.
EUROPEAN UROLOGY (2019)
A phase 1b dose escalation study of ipafricept (OMP-54F28) in combination with paclitaxel and carboplatin in patients with recurrent platinum-sensitive ovarian cancer
Kathleen N. Moore et al.
GYNECOLOGIC ONCOLOGY (2019)
Immune adjuvant therapy using Bacillus Calmette-Guerin cell wall skeleton (BCG-CWS) in advanced malignancies A phase 1 study of safety and immunogenicity assessments
Sumiyuki Nishida et al.
MEDICINE (2019)
Exosomes promote pre-metastatic niche formation in ovarian cancer
Wenlong Feng et al.
MOLECULAR CANCER (2019)
The anti-tumor function of the IKK inhibitor PS1145 and high levels of p65 and KLF4 are associated with the drug resistance in nasopharyngeal carcinoma cells
Hong Lok Lung et al.
SCIENTIFIC REPORTS (2019)
Verteporfin-Loaded Lipid Nanoparticles Improve Ovarian Cancer Photodynamic Therapy In Vitro and In Vivo
Thierry Michy et al.
CANCERS (2019)
Targeting Cancer Stemness in the Clinic: From Hype to Hope
Caner Saygin et al.
CELL STEM CELL (2019)
Long-term outcomes of imiquimod-treated lentigo maligna
M. Papanikolaou et al.
CLINICAL AND EXPERIMENTAL DERMATOLOGY (2019)
Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer
Richard L. Carpenter et al.
DRUG SAFETY (2019)
Preclinical development of the TLR9 agonist DV281 as an inhaled aerosolized immunotherapeutic for lung cancer: Pharmacological profile in mice, non-human primates, and human primary cells
Sariah A. Kell et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
Blockade of TLR4 using TAK-242 (resatorvid) enhances anti-cancer effects of chemotherapeutic agents: a novel synergistic approach for breast and ovarian cancers
Bahareh Kashani et al.
IMMUNOLOGIC RESEARCH (2019)
Verteporfin-Loaded Anisotropic Poly(Beta-Amino Ester)-Based Micelles Demonstrate Brain Cancer-Selective Cytotoxicity and Enhanced Pharmacokinetics
James G. Shamul et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)
An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability
Saad Sheikh et al.
MOLECULAR CANCER RESEARCH (2019)
Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment
Sandra Munoz-Galvan et al.
ONCOGENE (2019)
Plumbagin inhibits cancer stem-like cells, angiogenesis and suppresses cell proliferation and invasion by targeting Wnt/β-catenin pathway in endocrine resistant breast cancer
Nithidol Sakunrangsit et al.
PHARMACOLOGICAL RESEARCH (2019)
Local immunomodulation combined to radiofrequency ablation results in a complete cure of local and distant colorectal carcinoma
Katia Lemdani et al.
ONCOIMMUNOLOGY (2019)
Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment
Adele Chimento et al.
FRONTIERS IN ENDOCRINOLOGY (2019)
Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma
Shailender Bhatia et al.
CLINICAL CANCER RESEARCH (2019)
Verteporfin suppresses the proliferation, epithelial-mesenchymal transition and stemness of head and neck squamous carcinoma cells via inhibiting YAP1
Kui Liu et al.
JOURNAL OF CANCER (2019)
Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities
Philamer C. Calses et al.
TRENDS IN CANCER (2019)
An initial safety study of gedatolisib plus PTK7-ADC for metastatic triple-negative breast cancer
M. Radovich et al.
CANCER RESEARCH (2019)
Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD•Yap Protein-Protein Interaction
Khuchtumur Bum-Erdene et al.
CELL CHEMICAL BIOLOGY (2019)
SOX8 regulates cancer stem-like properties and cisplatin-induced EMT in tongue squamous cell carcinoma by acting on the Wnt/β-catenin pathway
S. -L. Xie et al.
INTERNATIONAL JOURNAL OF CANCER (2018)
Targeting Transcriptional Enhanced Associate Domains (TEADs)
Floriane Gibault et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T Cells
Y. Lai et al.
LEUKEMIA (2018)
A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma
Shumei Song et al.
MOLECULAR CANCER THERAPEUTICS (2018)
An open label, single-arm, phase II multicenter study of the safety and efficacy of CG0070 oncolytic vector regimen in patients with BCG-unresponsive non muscle-invasive bladder cancer: Interim results
Vignesh T. Packiam et al.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2018)
66PPharmacological activity of CB-103: An oral pan-NOTCH inhibitor targeting the NOTCH transcription complex
D Weber et al.
ANNALS OF ONCOLOGY (2018)
A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors
R. Ferrarotto et al.
ANNALS OF ONCOLOGY (2018)
A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma
Natalie Cook et al.
BRITISH JOURNAL OF CANCER (2018)
A highlight on Sonic hedgehog pathway
Gabriela Basile Carballo et al.
CELL COMMUNICATION AND SIGNALING (2018)
YAP and TAZ are essential for basal and squamous cell carcinoma initiation
Maud Debaugnies et al.
EMBO REPORTS (2018)
Modulation of the tumor microenvironment by intratumoral administration of IMO-2125, a novel TLR9 agonist, for cancer immunotherapy
Daqing Wang et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2018)
Toll like receptor signaling pathway as a potential therapeutic target in colorectal cancer
Reyhaneh Moradi-Marjaneh et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2018)
The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma
T. Fukusumi et al.
JOURNAL OF DENTAL RESEARCH (2018)
Five-Year Results of a Randomized Controlled Trial Comparing Effectiveness of Photodynamic Therapy, Topical Imiquimod, and Topical 5-Fluorouracil in Patients with Superficial Basal Cell Carcinoma
Maud H. E. Jansen et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)
Guidelines of care for the management of basal cell carcinoma
Christopher Bichakjian et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)
Dr. Jekyll and Mr. Hyde: MAP17's up-regulation, a crosspoint in cancer and inflammatory diseases
Jose M. Garcia-Heredia et al.
MOLECULAR CANCER (2018)
A multiprotein supercomplex controlling oncogenic signalling in lymphoma
James D. Phelan et al.
NATURE (2018)
YAP/TAZ upstream signals and downstream responses
Antonio Totaro et al.
NATURE CELL BIOLOGY (2018)
The Notch Pathway in Breast Cancer Progression
Emmanuel N. Kontomanolis et al.
TheScientificWorldJOURNAL (2018)
Effects of intravesical therapy with platelet-rich plasma (PRP) and Bacillus Calmette-Guerin (BCG) in non-muscle invasive bladder cancer
Lara Paro Dias et al.
TISSUE & CELL (2018)
The revival of CpG oligonucleotide-based cancer immunotherapies
Tomasz Adamus et al.
Wspolczesna Onkologia-Contemporary Oncology (2018)
ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells
Ching-Wen Chang et al.
CELL DEATH & DISEASE (2018)
YAP1 contributes to NSCLC invasion and migration by promoting Slug transcription via the transcription co-factor TEAD
Mengxue Yu et al.
CELL DEATH & DISEASE (2018)
EGFR-TKI resistance and MAP17 are associated with cancer stem cell like properties
Yi Shao et al.
ONCOLOGY LETTERS (2018)
The Notch Pathway in Breast Cancer Progression
Emmanuel N. Kontomanolis et al.
Scientific World Journal (2018)
Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/beta-Catenin Pathway in Chronic inflammation and Oxidative Stress During Carcinogenesis
Alexandre Vallee et al.
FRONTIERS IN IMMUNOLOGY (2018)
YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting
Federica Lo Sardo et al.
CANCERS (2018)
Inhibition of NF-kappa B Signaling Reduces the Sternness Characteristics of Lung Cancer Stem Cells
Norashikin Zakaria et al.
FRONTIERS IN ONCOLOGY (2018)
Notch Signaling in the Tumor Microenvironment
Olivier Meurette et al.
CANCER CELL (2018)
Biomarker analyses from a phase I study of WNT974, a first-in-class Porcupine inhibitor, in patients (pts) with advanced solid tumors
Jordi Rodon et al.
CANCER RESEARCH (2018)
MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma
Irene Ferrer et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)
Breast cancer stem cells: Features, key drivers and treatment options
Juergen Dittmer
SEMINARS IN CANCER BIOLOGY (2018)
In Situ Vaccination with a TLR9 Agonist and Local Low-Dose Radiation Induces Systemic Responses in Untreated Indolent Lymphoma
Matthew J. Frank et al.
CANCER DISCOVERY (2018)
MAP17 (PDZK1IP1) and pH2AX are potential predictive biomarkers for rectal cancer treatment efficacy
Maria Rivero et al.
Oncotarget (2018)
Toll-Like Receptor 4 (TLR4)/Cyclooxygenase-2 (COX-2) Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion by NF-κB Activation
Wei Wang et al.
MEDICAL SCIENCE MONITOR (2018)
TEAD4 overexpression promotes epithelial-mesenchymal transition and associates with aggressiveness and adverse prognosis in head neck squamous cell carcinoma
Wei Zhang et al.
CANCER CELL INTERNATIONAL (2018)
NF-κB, inflammation, immunity and cancer: coming of age
Koji Taniguchi et al.
NATURE REVIEWS IMMUNOLOGY (2018)
Roles of toll-like receptors: From inflammation to lung cancer progression
Jinjing Gu et al.
BIOMEDICAL REPORTS (2018)
The role of the Hedgehog signaling pathway in cancer: A comprehensive review
Ana Marija Skoda et al.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES (2018)
A randomized trial of TLR-2 agonist CADI-05 targeting desmocollin-3 for advanced non-small-cell lung cancer
C. P. Belani et al.
ANNALS OF ONCOLOGY (2017)
Sensing danger: toll-like receptors and outcome in allogeneic hematopoietic stem cell transplantation
B. Kornblit et al.
BONE MARROW TRANSPLANTATION (2017)
MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer
Federica Lo Sardo et al.
CARCINOGENESIS (2017)
Constitutive IRAK4 Activation Underlies Poor Prognosis and Chemoresistance in Pancreatic Ductal Adenocarcinoma
Daoxiang Zhang et al.
CLINICAL CANCER RESEARCH (2017)
Targeting the Hippo signalling pathway for cancer treatment
Keisuke Nakatani et al.
JOURNAL OF BIOCHEMISTRY (2017)
Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis)
Shivaani Kummar et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma
Wei Xiao et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)
High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells
Xi-Long Zhao et al.
JOURNAL OF PATHOLOGY (2017)
Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study
Charles M. Rudin et al.
LANCET ONCOLOGY (2017)
Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy
Li Li et al.
MEDICAL ONCOLOGY (2017)
Cancer stem cells revisited
Eduard Batlle et al.
NATURE MEDICINE (2017)
miR-302/367/LATS2/YAP pathway is essential for prostate tumor- propagating cells and promotes the development of castration resistance
Y. Guo et al.
ONCOGENE (2017)
TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis
Y. Zhou et al.
ONCOGENE (2017)
Effect of the acylation of TEAD4 on its interaction with co-activators YAP and TAZ
Yannick Mesrouze et al.
PROTEIN SCIENCE (2017)
Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation
Ilia A. Toshkov et al.
RADIATION RESEARCH (2017)
Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin
Jin Hai Zheng et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Glucocorticoid receptor signalling activates YAP in breast cancer
Giovanni Sorrentino et al.
NATURE COMMUNICATIONS (2017)
The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
Jose M. Garcia-Heredia et al.
ONCOTARGET (2017)
A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy
Yohei Takeda et al.
CELL REPORTS (2017)
Research progress in the treatment of small cell lung cancer
Yan-Fang Qiu et al.
JOURNAL OF CANCER (2017)
miRNA-34c-5p inhibits amphiregulin-induced ovarian cancer stemness and drug resistance via downregulation of the AREG-EGFR-ERK pathway
S-L Tung et al.
ONCOGENESIS (2017)
Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages
Elisabeth Mueller et al.
FRONTIERS IN IMMUNOLOGY (2017)
Topical Imiquimod Plus Nab-paclitaxel for Breast Cancer Cutaneous Metastases A Phase 2 Clinical Trial
Lupe G. Salazar et al.
JAMA ONCOLOGY (2017)
Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model
Giacomo Canesin et al.
PLOS ONE (2017)
NF-kappa B signaling in inflammation
Ting Liu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)
Drug Repurposing for the Treatment of Acute Myeloid Leukemia
Vibeke Andresen et al.
FRONTIERS IN MEDICINE (2017)
Long-Term Survival after Complete Surgical Resection and Adjuvant Immunotherapy for Distant Melanoma Metastases
Mark B. Faries et al.
ANNALS OF SURGICAL ONCOLOGY (2017)
Stress stimuli induce cancer-sternness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma
Kwang-Yu Chang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer
Alexandre Prieur et al.
CLINICAL CANCER RESEARCH (2017)
Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer
Fumi Sato-Kaneko et al.
JCI INSIGHT (2017)
Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness
Hitoshi Takizawa et al.
CELL STEM CELL (2017)
The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB
Jose Manuel Garcia-Heredia et al.
CLINICAL CANCER RESEARCH (2017)
A phase I study of the safety and immunogenicity of a multipeptide personalized genomic vaccine in the adjuvant treatment of solid cancers.
Chrisann Kyi et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression
Alvaro G. Alvarado et al.
CELL STEM CELL (2017)
A randomized pilot trial testing the safety and immunologic effects of a MAGE-A3 protein plus AS15 immunostimulant administered into muscle or into dermal/subcutaneous sites
Craig L. Slingluff et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)
Bulk pancreatic cancer cells can convert into cancer stem cells(CSCs) in vitro and 2 compounds can target these CSCs
Xiaoyan Ning et al.
CELL CYCLE (2016)
Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner
Y. Liu et al.
ONCOGENE (2016)
Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors
I. Ferrer et al.
ONCOGENE (2016)
YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage
E. Ciamporcero et al.
ONCOGENE (2016)
Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells
Haiying Cheng et al.
ONCOTARGET (2016)
Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells
Ronghua Wang et al.
ONCOTARGET (2016)
The hypoxic microenvironment: A determinant of cancer stem cell evolution
Amancio Carnero et al.
BIOESSAYS (2016)
Sensitizing ovarian cancer cells to chemotherapy by interfering with pathways that are involved in the formation of cancer stem cells
Kamola Saydaminova et al.
CANCER BIOLOGY & THERAPY (2016)
Topical treatment of melanoma metastases with imiquimod, plus administration of a cancer vaccine, promotes immune signatures in the metastases
Ileana S. Mauldin et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)
Notch4+cancer stem-like cells promote the metastatic and invasive ability of melanoma
Xian Lin et al.
CANCER SCIENCE (2016)
The cancer stem-cell signaling network and resistance to therapy
A. Carnero et al.
CANCER TREATMENT REVIEWS (2016)
Non-Photoinduced Biological Properties of Verteporfin
Floriane Gibault et al.
CURRENT MEDICINAL CHEMISTRY (2016)
TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice
Dinesh Babu Uthaya Kumar et al.
GASTROENTEROLOGY (2016)
Cancer stem cells: understanding tumor hierarchy and heterogeneity
Jeremy N. Rich
MEDICINE (2016)
Cancer stem cell signaling pathways
William H. Matsui
MEDICINE (2016)
Characterization of Hippo Pathway Components by Gene Inactivation
Steven W. Plouffe et al.
MOLECULAR CELL (2016)
Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway
PuiYee Chan et al.
NATURE CHEMICAL BIOLOGY (2016)
Notch signalling in context
Sarah J. Bray
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling
Cameron L. Noland et al.
STRUCTURE (2016)
High-dose irradiation in combination with toll-like receptor 9 agonist CpG oligodeoxynucleotide 7909 downregulates PD-L1 expression via the NF-κB signaling pathway in non-small cell lung cancer cells
Xue Chen et al.
ONCOTARGETS AND THERAPY (2016)
ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
Waltraut Lehmann et al.
NATURE COMMUNICATIONS (2016)
In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors
Monica Benvenuto et al.
ONCOTARGET (2016)
Numb-Like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy
Jose M. Garcia-Heredia et al.
ONCOTARGET (2016)
Cisplatin induces stemness in ovarian cancer
Andrew Wiechert et al.
ONCOTARGET (2016)
NF-kappaB-inducing kinase regulates stem cell phenotype in breast cancer
Karla Vazquez-Santillan et al.
SCIENTIFIC REPORTS (2016)
Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells
Tian-yi Zhou et al.
SCIENTIFIC REPORTS (2016)
Adjuvant Autologous Melanoma Vaccine for Macroscopic Stage III Disease: Survival, Biomarkers, and Improved Response to CTLA-4 Blockade
Michal Lotem et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2016)
Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
Tadas K. Rimkus et al.
CANCERS (2016)
Metformin in Cancer Treatment and Prevention
Daniel R. Morales et al.
ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)
Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma
Alain H. Rook et al.
BLOOD (2015)
Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma
Hayley J. Sharpe et al.
CANCER CELL (2015)
Toll like receptor 4 facilitates invasion and migration as a cancer stem cell marker in hepatocellular carcinoma
Wen-Ting Liu et al.
CANCER LETTERS (2015)
Notch signaling: An emerging therapeutic target for cancer treatment
Xun Yuan et al.
CANCER LETTERS (2015)
RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells
Matthias Ilmer et al.
CANCER RESEARCH (2015)
Cell-of-Origin of Cancer versus Cancer Stem Cells: Assays and Interpretations
Kiera Rycaj et al.
CANCER RESEARCH (2015)
Disruptive chemicals, senescence and immortality
Amancio Carnero et al.
CARCINOGENESIS (2015)
Alternative Wnt Signaling Activates YAP/TAZ
Hyun Woo Park et al.
CELL (2015)
The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
Vicki Plaks et al.
CELL STEM CELL (2015)
Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade
Yonggang Zheng et al.
DEVELOPMENTAL CELL (2015)
Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?
Axel Schulenburg et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)
MAP17 (PDZKIP1) Expression Determines Sensitivity to the Proteasomal Inhibitor Bortezomib by Preventing Cytoprotective Autophagy and NFκB Activation in Breast Cancer
Sandra Munoz-Galvan et al.
MOLECULAR CANCER THERAPEUTICS (2015)
Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases
Xiaomo Jiang et al.
MOLECULAR CELL (2015)
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies
Luping Lin et al.
NATURE GENETICS (2015)
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
Naoko Takebe et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2015)
MYD88 Mutations and Response to Ibrutinib in Waldenstrom's Macroglobulinemia
Steven P. Treon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28
Phuong N. Le et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Poly(I:C) as cancer vaccine adjuvant: Knocking on the door of medical breakthroughs
Rachid Ammi et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Radiation resistance: Cancer stem cells (CSCs) and their enigmatic pro-survival signaling
Ira Skvortsova et al.
SEMINARS IN CANCER BIOLOGY (2015)
Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy
Ajaybabu V. Pobbati et al.
STRUCTURE (2015)
CpG oligodeoxyribonucleotide 7909 enhances radiosensitivity via downregulating Oct-4 expression in radioresistant lung cancer cells
Na Xing et al.
ONCOTARGETS AND THERAPY (2015)
Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling
Lishan Fang et al.
NATURE COMMUNICATIONS (2015)
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
Zhipeng Meng et al.
NATURE COMMUNICATIONS (2015)
Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
Upal Basu-Roy et al.
NATURE COMMUNICATIONS (2015)
A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma
Cristina Papayannidis et al.
BLOOD CANCER JOURNAL (2015)
The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1
Chunyan Wang et al.
ONCOTARGET (2015)
Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain
Jose M. Garcia-Heredia et al.
ONCOTARGET (2015)
TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells
Dayson Moreira et al.
ONCOTARGET (2015)
Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling
Anja Heinemann et al.
ONCOTARGET (2015)
Resiquimod as an Immunologic Adjuvant for NY-ESO-1 Protein Vaccination in Patients with High-Risk Melanoma
Rachel Lubong Sabado et al.
CANCER IMMUNOLOGY RESEARCH (2015)
Hedgehog Signaling in the Maintenance of Cancer Stem Cells
Catherine R. Cochrane et al.
CANCERS (2015)
Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling
Shuangxi Li et al.
CELL DISCOVERY (2015)
Cancer stem cell plasticity and tumor hierarchy
Marina Carla Cabrera et al.
WORLD JOURNAL OF STEM CELLS (2015)
Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma
Yao-An Shen et al.
CELL CYCLE (2015)
β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer
D. Jia et al.
CELL DEATH AND DIFFERENTIATION (2015)
A Phase I, Dose-Finding Study in Patients with Advanced Solid Malignancies of the Oral gamma-Secretase Inhibitor PF-03084014
Wells A. Messersmith et al.
CLINICAL CANCER RESEARCH (2015)
Molecular Pathways: Translational and Therapeutic Implications of the Notch Signaling Pathway in Cancer
Rebecca A. Previs et al.
CLINICAL CANCER RESEARCH (2015)
TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells
M. Bartucci et al.
ONCOGENE (2015)
A phase I study of the toll-like receptor 5 (TLR5) agonist, entolimod in patients (pts) with advanced cancers.
Hatoon Bakhribah et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3+ regulatory T cells in MRL/lpr mice
Tomohiro Koga et al.
AUTOIMMUNITY (2014)
Targeting antioxidants for cancer therapy
Andrea Glasauer et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling
Andreas Herbst et al.
BMC GENOMICS (2014)
From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling
Panagiotis Ntziachristos et al.
CANCER CELL (2014)
A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
Shi Jiao et al.
CANCER CELL (2014)
The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma
Verline Justilien et al.
CANCER CELL (2014)
TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting
Andreas Herrmann et al.
CANCER RESEARCH (2014)
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
Diane D. Shao et al.
CELL (2014)
The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation
Katarzyna Brodowska et al.
EXPERIMENTAL EYE RESEARCH (2014)
A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis
Qian Chen et al.
GENES & DEVELOPMENT (2014)
Cancer stem cell: A rogue responsible for tumor development and metastasis
Aditi Kapoor et al.
INDIAN JOURNAL OF CANCER (2014)
WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors
Jamie N. Anastas et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF-β, and Wnt Signaling Pathways
Dipanjan Basu et al.
MOLECULAR CANCER THERAPEUTICS (2014)
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
Soufiane Boumahdi et al.
NATURE (2014)
Tackling the cancer stem cells - what challenges do they pose?
Diwakar R. Pattabiraman et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Cellular senescence: from physiology to pathology
Daniel Munoz-Espin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
The PIM Family of Serine/Threonine Kinases in Cancer
Maja Narlik-Grassow et al.
MEDICINAL RESEARCH REVIEWS (2014)
SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma
B. Mao et al.
ONCOGENE (2014)
Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1
Dayeon Yu et al.
ONCOLOGY REPORTS (2014)
Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Jan Kroenke et al.
SCIENCE (2014)
How Thalidomide Works Against Cancer
A. Keith Stewart
SCIENCE (2014)
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
Hans Clevers et al.
SCIENCE (2014)
Hippo Signaling Mediates Proliferation, Invasiveness, and Metastatic Potential of Clear Cell Renal Cell Carcinoma
Ute Schuette et al.
TRANSLATIONAL ONCOLOGY (2014)
The pentose phosphate pathway and cancer
Krushna C. Patra et al.
TRENDS IN BIOCHEMICAL SCIENCES (2014)
Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction
Zhisen Zhang et al.
ACS MEDICINAL CHEMISTRY LETTERS (2014)
YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression
Yijun Gao et al.
NATURE COMMUNICATIONS (2014)
Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice
Bojidar M. Kojouharov et al.
ONCOTARGET (2014)
Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis
Masanori Okamoto et al.
SCIENTIFIC REPORTS (2014)
Regulation of the pentose phosphate pathway in cancer
Peng Jiang et al.
PROTEIN & CELL (2014)
Expression of Hippo Pathway in Colorectal Cancer
Kun Liang et al.
SAUDI JOURNAL OF GASTROENTEROLOGY (2014)
Therapeutic In Situ Autovaccination against Solid Cancers with Intratumoral Poly-ICLC: Case Report, Hypothesis, and Clinical Trial
Andres M. Salazar et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts
Suling Liu et al.
STEM CELL REPORTS (2014)
Toll-like receptors and cancer: MYD88 mutation and inflammation
James Q. Wang et al.
FRONTIERS IN IMMUNOLOGY (2014)
Cancer stem cell immunology: key to understanding tumorigenesis and tumor immune escape?
Valentin S. Bruttel et al.
FRONTIERS IN IMMUNOLOGY (2014)
Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?
Christen L Walters Haygood
World Journal of Stem Cells (2014)
Cancer Stem Cells and Their Mechanism of Chemo-Radiation Resistance
Yonghyun Kim et al.
International Journal of Stem Cells (2014)
Cancer stem cells - the current status of an old concept: literature review and clinical approaches
Lukasz Fulawka et al.
BIOLOGICAL RESEARCH (2014)
The Safety and Activity of BMS-906024, a Gamma Secretase Inhibitor (GSI) with Anti-Notch Activity, in Patients with Relapsed T-Cell Acute Lymphoblastic Leukemia (T-ALL): Initial Results of a Phase 1 Trial
Patrick A. Zweidler-McKay et al.
BLOOD (2014)
Oxidative stress and cancer: An overview
Venus Sosa et al.
AGEING RESEARCH REVIEWS (2013)
Effects of the Hippo Signaling Pathway in Human Gastric Cancer
Guang-Xi Zhou et al.
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2013)
Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities
Carmen Blanco-Aparicio et al.
BIOCHEMICAL PHARMACOLOGY (2013)
Understanding breast cancer stem cell heterogeneity: time to move on to a new research paradigm
Ferdinando Mannello
BMC MEDICINE (2013)
A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1
Weizhou Zhang et al.
CANCER CELL (2013)
Cancer stem cell dynamics in tumor progression and metastasis: Is the microenvironment to blame?
Evelyn Fessler et al.
CANCER LETTERS (2013)
Capturing the mammalian Hippo: Elucidating its role in cancer
Miki Nishio et al.
CANCER SCIENCE (2013)
TLR2 enhances ovarian cancer stem cell self-renewal and promotes tumor repair and recurrence
Ilana Chefetz et al.
CELL CYCLE (2013)
Poised with purpose Cell plasticity enhances tumorigenicity
Nemanja D. Marjanovic et al.
CELL CYCLE (2013)
BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
Eleni D. Lagadinou et al.
CELL STEM CELL (2013)
Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors
Anne F. Schott et al.
CLINICAL CANCER RESEARCH (2013)
Cell Plasticity and Heterogeneity in Cancer
Nemanja D. Marjanovic et al.
CLINICAL CHEMISTRY (2013)
Wnt signaling in stem and cancer stem cells
Jane D. Holland et al.
CURRENT OPINION IN CELL BIOLOGY (2013)
Resiquimod, a topical drug for viral skin lesions and skin cancer
Thomas Meyer et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2013)
Perturbation of proteasome function by bortezomib leading to ER stress-induced apoptotic cell death in cholangiocarcinoma
Kulthida Vaeteewoottacharn et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2013)
Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells
Chia-Lin Chen et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
The complexity of NF-κB signaling in inflammation and cancer
Bastian Hoesel et al.
MOLECULAR CANCER (2013)
Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer
Luca Magnani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist
Lyudmila G. Burdelya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Constitutive Activation of RANK Disrupts Mammary Cell Fate Leading to Tumorigenesis
Pellegrini Pasquale et al.
STEM CELLS (2013)
Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli
Jin-bin Han et al.
ONCOTARGETS AND THERAPY (2013)
NF-kappa B non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype
Mizuki Yamamoto et al.
NATURE COMMUNICATIONS (2013)
Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2
Michael P. O'Connell et al.
CANCER DISCOVERY (2013)
Tamoxifen-resistant breast cancer cells possess cancer stem-like cell properties
Liu Hui et al.
CHINESE MEDICAL JOURNAL (2013)
MAP17 and the double-edged sword of ROS
Amancio Carnero
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2012)
Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma
Simona Blotta et al.
BLOOD (2012)
Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1
Jing Fang et al.
BLOOD (2012)
Cancer stem cells and EMT in carcinoma
Adrian Biddle et al.
CANCER AND METASTASIS REVIEWS (2012)
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Dianne H. Dapito et al.
CANCER CELL (2012)
Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin
Shoaib Afzal et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2012)
CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma
Lian Shu Piao et al.
CANCER LETTERS (2012)
Opposing effects of bortezomib-induced nuclear factor-κB inhibition on chemical lung carcinogenesis
Sophia P. Karabela et al.
CARCINOGENESIS (2012)
Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML
Florian H. Heidel et al.
CELL STEM CELL (2012)
Treatment With OPN-305, a Humanized Anti-Toll-Like Receptor-2 Antibody, Reduces Myocardial Ischemia/Reperfusion Injury in Pigs
Fatih Arslan et al.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS (2012)
A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas
David S. Hong et al.
CLINICAL CANCER RESEARCH (2012)
A phase II study of RO4929097 in metastatic colorectal cancer
Jonathan R. Strosberg et al.
EUROPEAN JOURNAL OF CANCER (2012)
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
Yi Liu-Chittenden et al.
GENES & DEVELOPMENT (2012)
Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
Bin Zhao et al.
GENES & DEVELOPMENT (2012)
Immunotherapeutic efficacy of Mycobacterium indicus pranii in eliciting anti-tumor T cell responses: Critical roles of IFNγ
Srabanti Rakshit et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia
Clive S. Zent et al.
LEUKEMIA & LYMPHOMA (2012)
Cancer stem cells and drug resistance: the potential of nanomedicine
Serguei Vinogradov et al.
NANOMEDICINE (2012)
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
Sergei I. Grivennikov et al.
NATURE (2012)
Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model
Yifeng Xia et al.
NATURE CELL BIOLOGY (2012)
Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation
A. Fernandez-L et al.
ONCOGENE (2012)
Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation
S. M. Kumar et al.
ONCOGENE (2012)
Inflammation linking EMT and cancer stem cells
Chenchen Zhou et al.
ORAL ONCOLOGY (2012)
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain
John M. Lamar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The Hedgehog Signal Transduction Network
David J. Robbins et al.
SCIENCE SIGNALING (2012)
Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses
Johan Garaude et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
The YAP and TAZ transcription co-activators: Key downstream effectors of the mammalian Hippo pathway
Wanjin Hong et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)
Frizzled and LRP5/6 Receptors for Wnt/β-Catenin Signaling
Bryan T. MacDonald et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)
CpG Still Rocks! Update on an Accidental Drug
Arthur M. Krieg
NUCLEIC ACID THERAPEUTICS (2012)
Cancer Stem Cells Stemness Transcription Factors Expression Correlates with Breast Cancer Disease Stage
Panagiotis Apostolou et al.
CURRENT STEM CELL RESEARCH & THERAPY (2012)
Microenvironmental Regulation of Cancer Stem Cell Phenotypes
Daniela F. Quail et al.
Current Stem Cell Research & Therapy (2012)
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
Richard C. Scarpulla
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
Epigenetic mechanisms in senescence, immortalisation and cancer
Amancio Carnero et al.
BIOLOGICAL REVIEWS (2011)
Cancer Stem Cell Niche: The Place to Be
Tijana Borovski et al.
CANCER RESEARCH (2011)
The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells
Michelangelo Cordenonsi et al.
CELL (2011)
Toll-like receptor modulators: a patent review (2006-2010)
Shaherin Basith et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2011)
The miR-143/145 Cluster Is a Novel Transcriptional Target of Jagged-1/Notch Signaling in Vascular Smooth Muscle Cells
Joshua M. Boucher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Engineering Dendritic Cells to Enhance Cancer Immunotherapy
Jeanette E. Boudreau et al.
MOLECULAR THERAPY (2011)
Inflammation meets cancer, with NF-κB as the matchmaker
Yinon Ben-Neriah et al.
NATURE IMMUNOLOGY (2011)
miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response
Bogdan Mateescu et al.
NATURE MEDICINE (2011)
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
Christine L. Chaffer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
Dimitrios Anastasiou et al.
SCIENCE (2011)
Response and Resistance to NF-κB Inhibitors in Mouse Models of Lung Adenocarcinoma
Wen Xue et al.
CANCER DISCOVERY (2011)
Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
Frank Kuhnert et al.
VASCULAR CELL (2011)
The Canonical NF-κB Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion
Manran Liu et al.
CANCER RESEARCH (2010)
Immunity, Inflammation, and Cancer
Sergei I. Grivennikov et al.
CELL (2010)
Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer
Srinivas Nagaraj et al.
CLINICAL CANCER RESEARCH (2010)
Understanding FOXO, New Views on Old Transcription Factors
F. Zanella et al.
CURRENT CANCER DRUG TARGETS (2010)
The PKB/AKT Pathway in Cancer
Amancio Carnero
CURRENT PHARMACEUTICAL DESIGN (2010)
Hedgehog controls neural stem cells through p53-independent regulation of Nanog
Agnese Po et al.
EMBO JOURNAL (2010)
Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression
Martin Grimm et al.
EUROPEAN JOURNAL OF CANCER (2010)
Inflammation and Colon Cancer
Janos Terzic et al.
GASTROENTEROLOGY (2010)
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF beta-TRCP
Bin Zhao et al.
GENES & DEVELOPMENT (2010)
Amphiregulin Promotes BAX Inhibition and Resistance to Gefitinib in Non-small-cell Lung Cancers
Benoit Busser et al.
MOLECULAR THERAPY (2010)
Therapeutic antibody targeting of individual Notch receptors
Yan Wu et al.
NATURE (2010)
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Louis Vermeulen et al.
NATURE CELL BIOLOGY (2010)
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai et al.
NATURE IMMUNOLOGY (2010)
DAMPening Inflammation by Modulating TLR Signalling
A. M. Piccinini et al.
MEDIATORS OF INFLAMMATION (2010)
Changes of AXIN-1 and Beta-Catenin in Neuroepithelial Brain Tumors
Tamara Nikuseva Martic et al.
PATHOLOGY & ONCOLOGY RESEARCH (2010)
Gβγ Activates GSK3 to Promote LRP6-Mediated β-Catenin Transcriptional Activity
Kristin K. Jernigan et al.
SCIENCE SIGNALING (2010)
Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents
Sreenath V. Sharma et al.
NATURE REVIEWS CANCER (2010)
Phase II Trial of Thalidomide, Irinotecan and Gemcitabine in Chemonaive Patients with Advanced Non-Small Cell Lung Cancer
A. R. Jazieh et al.
CANCER INVESTIGATION (2009)
Angiogenesis: A Team Effort Coordinated by Notch
L. -K. Phng et al.
DEVELOPMENTAL CELL (2009)
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A
Yumi Yashiro-Ohtani et al.
GENES & DEVELOPMENT (2009)
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
Africa Fernandez-L et al.
GENES & DEVELOPMENT (2009)
TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition
Heng Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Maximilian Diehn et al.
NATURE (2009)
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
Jianmin Zhang et al.
NATURE CELL BIOLOGY (2009)
Cancer stem cells: mirage or reality?
Piyush B. Gupta et al.
NATURE MEDICINE (2009)
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Dunyaporn Trachootham et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
J. M. Bailey et al.
ONCOGENE (2009)
NF-κB as a Critical Link Between Inflammation and Cancer
Michael Karin
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection
Patricia A. Taylor et al.
BLOOD (2008)
TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical outcome in prostate cancer
J. F. Knight et al.
BRITISH JOURNAL OF CANCER (2008)
Cell cycle-dependent ciliogenesis and cancer
Olga V. Plotnikova et al.
CANCER RESEARCH (2008)
Shared principles in NF-κB signaling
Matthew S. Hayden et al.
CELL (2008)
Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant
C. R. Casella et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma
Shih-Hwa Chiou et al.
CLINICAL CANCER RESEARCH (2008)
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
Amancio Carnero et al.
CURRENT CANCER DRUG TARGETS (2008)
Hedgehog: functions and mechanisms
Markku Varjosalo et al.
GENES & DEVELOPMENT (2008)
TEAD mediates YAP-dependent gene induction and growth control
Bin Zhao et al.
GENES & DEVELOPMENT (2008)
DNA copy number alterations and expression of relevant genes in triple-negative breast cancer
Wonshik Han et al.
GENES CHROMOSOMES & CANCER (2008)
Impact of antioxidant supplementation on chemotherapeutic toxicity: A systematic review of the evidence from randomized controlled trials
Keith I. Block et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
The molecular logic of Notch signaling - a structural and biochemical perspective
Wendy R. Gordon et al.
JOURNAL OF CELL SCIENCE (2008)
Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant
Sylvia Adams et al.
JOURNAL OF IMMUNOLOGY (2008)
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
Qun-Ying Lei et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Bortezomib-resistant nuclear Factor-κB activity in multiple myeloma cells
Stephanie Markovina et al.
MOLECULAR CANCER RESEARCH (2008)
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
Allyson E. Vaughn et al.
NATURE CELL BIOLOGY (2008)
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
Xaralabos Varelas et al.
NATURE CELL BIOLOGY (2008)
Role of Toll-like receptors in gastrointestinal malignancies
M. Fukata et al.
ONCOGENE (2008)
Rational targeting of Notch signaling in cancer
P. Rizzo et al.
ONCOGENE (2008)
Notch signaling regulates tumor angiogenesis by diverse mechanisms
J. Dufraine et al.
ONCOGENE (2008)
Generation of human induced pluripotent stem cells from dermal fibroblasts
W. E. Lowry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Hedgehog signaling is essential for normal wound healing
Huong Le et al.
WOUND REPAIR AND REGENERATION (2008)
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Jane E. Visvader et al.
NATURE REVIEWS CANCER (2008)
Telomere length, stem cells and aging
Maria A. Blasco
NATURE CHEMICAL BIOLOGY (2007)
Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model
Takukyu Sha et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Toll-like receptors in inflammation, infection and cancer
Keqiang Chen et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2007)
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
Insa Geffers et al.
JOURNAL OF CELL BIOLOGY (2007)
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
Luke A. J. O'Neill et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
Craig D. Peacock et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
Virginie Clement et al.
CURRENT BIOLOGY (2007)
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
Eli E. Bar et al.
STEM CELLS (2007)
The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network
Kieran Harvey et al.
NATURE REVIEWS CANCER (2007)
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
John Ridgway et al.
NATURE (2006)
Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response
Jennifer Sims-Mourtada et al.
CLINICAL CANCER RESEARCH (2006)
Mutations in the NF-κB signaling pathway:: implications for human disease
G. Courtois et al.
ONCOGENE (2006)
Imiquimod in the treatment of lentigo maligna
S. F. Rajpar et al.
BRITISH JOURNAL OF DERMATOLOGY (2006)
Antiviral action of the tumor suppressor ARF
Maria A. Garcia et al.
EMBO JOURNAL (2006)
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
Michael Overholtzer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Immunobiology of Toll-like receptors: Emerging trends
Saumya Pandey et al.
IMMUNOLOGY AND CELL BIOLOGY (2006)
Protein kinase casein kinase 2 mediates inhibitor-κB kinase and aberrant nuclear factor-κB activation by serum factor(s) in head and neck squamous carcinoma cells
Mng Yu et al.
CANCER RESEARCH (2006)
NF-κB and cancer:: Mechanisms and targets
Michael Karin
MOLECULAR CARCINOGENESIS (2006)
Pathogen recognition and innate immunity
S Akira et al.
CELL (2006)
Molecular linkage between the kinase ATM and NF-κB signaling in response to genotoxic stimuli (Publication with Expression of Concern. See vol. 371, pg. 1002, 2021)
ZH Wu et al.
SCIENCE (2006)
Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors
JE Korkola et al.
CANCER RESEARCH (2006)
TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy
K. Hoebe et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Effects of IKK inhibitor PS1145 on NF-kappa B function, proliferation, apoptosis and invasion activity in prostate carcinoma cells
A Yemelyanov et al.
ONCOGENE (2006)
Therapeutic potential of Toll-like receptor 9 activation
Arthur M. Krieg
NATURE REVIEWS DRUG DISCOVERY (2006)
The antioxidant function of the p53 tumor suppressor
AA Sablina et al.
NATURE MEDICINE (2005)
Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
NS Patel et al.
CANCER RESEARCH (2005)
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
E Ladi et al.
JOURNAL OF CELL BIOLOGY (2005)
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
DC Radisky et al.
NATURE (2005)
A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease
MM Fort et al.
JOURNAL OF IMMUNOLOGY (2005)
A novel NF-κB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors
A Tanaka et al.
BLOOD (2005)
Role of reactive oxygen species in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
DY Rhyu et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)
Toll-like receptor control of the adaptive immune responses
A Iwasaki et al.
NATURE IMMUNOLOGY (2004)
Genetic and epigenetic alterations of the APC gene in malignant melanoma
J Worm et al.
ONCOGENE (2004)
Activation of the hedgehog pathway in advanced prostate cancer
Tao Sheng et al.
MOLECULAR CANCER (2004)
Dosage-sensitive requirement for mouse D114 in artery development
A Duarte et al.
GENES & DEVELOPMENT (2004)
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
H Gerhardt et al.
JOURNAL OF CELL BIOLOGY (2003)
The Toll-IL-1 receptor adaptor family grows to five members
LAJ O'Neill et al.
TRENDS IN IMMUNOLOGY (2003)
Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family
MU Martin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2002)
Inhibition of PTPS by H2O2 regulates the activation of distinct MAPK pathways
K Lee et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
NF-κB regulation in the immune system
QT Li et al.
NATURE REVIEWS IMMUNOLOGY (2002)
ROS, stress-activated kinases and stress signaling in cancer
M Benhar et al.
EMBO REPORTS (2002)
Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells
ML Guzman et al.
BLOOD (2001)
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
C Wang et al.
NATURE (2001)
Increased formation of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes
A Matsui et al.
CANCER LETTERS (2000)
Share Paper
