Journal
CELLS
Volume 9, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/cells9102148
Keywords
non-alcoholic fatty liver disease; oxidative stress; liver damage; inflammation; NLRP3-inflammasome complex
Categories
Funding
- Nicolas Monardes Program from Servicio Andaluz de Salud (SAS)
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Aging is associated with metabolic changes and low-grade inflammation in several organs, which may be due to NLRP3 inflammasome activation. Methods: Here, we asked whether age-related liver changes such as lipid metabolism and fibrosis are reduced in aged mice lacking the NLRP3 inflammasome. We report reduced protein levels of lipid markers (MTP, FASN, DGAT1), SOD activity, oxidative stress marker PTPRG, and the fibrotic markers TPM2 beta, COL1-alpha 1 associated with increased GATA4, in NLRP3 deficient mice. Fibrotic, lipid, and oxidative reduction in liver tissues of mice was more pronounced in those old KO NLRP3 mice than in the younger ones, despite their greater liver damage. These results suggest that absence of the NLRP3 inflammasome attenuates age-related liver fibrotic pathology in mice, suggesting that pharmacological targeting may be beneficial.
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