Journal
CELLS
Volume 9, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/cells9091949
Keywords
bile acid; tight junction; Th2; liver fibrosis; bacterial translocation; intestinal microbiome
Categories
Funding
- Behring-Roentgen Foundation [60-0002]
- Deutsche Forschungsgemeinschaft [RO 957/10-1, RO 957/11, RO 3714/4, KFO 217, KFO309, SFB1021, SFB-TR84, SFB/TRR57]
- German Center for Infection research (DZIF)
- Interdisciplinary Centre for Clinical Research within the Faculty of Medicine at the RWTH Aachen University (IZKF Aachen) [O3-1]
Ask authors/readers for more resources
The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in anAbcb4-knockout mouse model (Abcb4(-/-)). Lack of IL-13 protectedAbcb4(-/-)mice transiently from cholestasis. This decrease in serum bile acids was accompanied by an enhanced excretion of bile acids and a normalization of fecal bile acid composition. InAbcb4(-/-)/IL-13(-/-)double knockout mice, bacterial translocation to the liver was significantly reduced and the intestinal microbiome resembled the commensal composition in wild type animals. In addition, 52-week-oldAbcb4(-/-)IL-13(-/-)mice showed significantly reduced hepatic fibrosis.Abcb4(-/-)mice devoid of IL-13 transiently improved cholestasis and converted the composition of the gut microbiota towards healthy conditions. This highlights IL-13 as a potential therapeutic target in biliary diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
