Journal
CELLS
Volume 9, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/cells9102264
Keywords
murine reporter models; cell signaling pathways; fluorescent reporter proteins; hematopoietic stem cell biology; murine multi-reporter
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Funding
- Leiden University
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Hematopoietic stem cells (HSCs) develop at several anatomical locations and are thought to undergo different niche regulatory cues originating from highly conserved cell signaling pathways, such as Wnt, Notch, TGF-beta family, and Hedgehog signaling. Most insight into these pathways has been obtained by reporter models and loss- or gain of function experiments, yet results differ in many cases according to the approach. In this review, we discuss existing murine reporter models regarding these pathways, considering the genetic constructs and reporter proteins in the context of HSC studies; yet these models are relevant for all other stem cell systems. Lastly, we describe a multi-reporter model to properly study and understand the cross-pathway interaction and how reporter models are highly valuable tools to understand complex signaling dynamics in stem cells.
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