4.6 Review

The Neurokinin-1 Receptor Antagonist Aprepitant: An Intelligent Bullet against Cancer?

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Drug Repositioning in Oncology

Marissa B. Serafin et al.

Summary: Drug repositioning is considered an alternative strategy for fast drug identification, but financial and regulatory obstacles need to be addressed to stimulate the involvement of the pharmaceutical industry.

AMERICAN JOURNAL OF THERAPEUTICS (2021)

Article Critical Care Medicine

Aprepitant for Cough Suppression in Advanced Lung Cancer A Randomized Trial

Vanita Noronha et al.

CHEST (2020)

Article Chemistry, Medicinal

Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects

Meng-Jie Yang et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

Article Chemistry, Medicinal

The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages

Xiao-nan Zhao et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

Article Medicine, Research & Experimental

TGF beta regulates NK1R-Tr to affect the proliferation and apoptosis of breast cancer cells

Lushan Wang et al.

LIFE SCIENCES (2020)

Article Pharmacology & Pharmacy

A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity

Harun Un et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Article Chemistry, Medicinal

Aprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo

Hongzhang Wu et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

Article Cell Biology

SP/NK-1R promotes gallbladder cancer cell proliferation and migration

Xue-Ting Deng et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Review Chemistry, Medicinal

Neurokinin-1 Receptor Antagonists as Anticancer Drugs

Miguel Munoz et al.

LETTERS IN DRUG DESIGN & DISCOVERY (2019)

Article Biochemistry & Molecular Biology

Evaluation of serum level of substance P and tissue distribution of NK-1 receptor in breast cancer

Monireh Davoodian et al.

MOLECULAR BIOLOGY REPORTS (2019)

Article Biochemistry & Molecular Biology

The neurokinin-1 receptor antagonist aprepitant ameliorates oxidized LDL-induced endothelial dysfunction via KLF2

Jianghua Zheng et al.

MOLECULAR IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

SP promotes cell proliferation in esophageal squamous cell carcinoma through the NK1R/Hes1 axis

Fei Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Biotechnology & Applied Microbiology

Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes

Xiaoping Liu et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

Review Biochemistry & Molecular Biology

The emerging role of substance P/neurokinin-1 receptor signaling pathways in growth and development of tumor cells

Hossein Javid et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2019)

Article Dermatology

Neurokinin 1 receptor antagonists exhibit peripheral effects in prurigo nodularis including reduced ERK1/2 activation

K. Agelopoulos et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

Article Multidisciplinary Sciences

Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload

Chentao Ge et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Oncology

Neurokinin-1 Receptor Antagonists against Hepatoblastoma

Miguel Munoz et al.

CANCERS (2019)

Review Pharmacology & Pharmacy

The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy

Agnieszka Majkowska-Pilip et al.

PHARMACEUTICS (2019)

Article Pediatrics

Evaluation of aprepitant and fosaprepitant in pediatric patients

Yoshimasa Saito et al.

PEDIATRICS INTERNATIONAL (2019)

Article Multidisciplinary Sciences

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

Jendrik Schoeppe et al.

NATURE COMMUNICATIONS (2019)

Article Pharmacology & Pharmacy

Emerging targets for cough therapies; NK1 receptor antagonists

Huda Badri et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2019)

Article Oncology

miR-206 Promotes Cancer Progression by Targeting Full-Length Neurokinin-1 Receptor in Breast Cancer

Yu Zhou et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2019)

Review Oncology

Perioperative events influence cancer recurrence risk after surgery

Jonathan G. Hiller et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Medicine, Research & Experimental

MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural invasion of pancreatic cancer cells

Chumei Huang et al.

THERANOSTICS (2018)

Review Psychiatry

Biological Mechanisms of Cancer-Induced Depression

Kimberly Young et al.

FRONTIERS IN PSYCHIATRY (2018)

Article Biochemistry & Molecular Biology

Evaluation of serum level of substance P and tissue distribution of NK-1 receptor in endometrial cancer

Naghmeh Gharaee et al.

MOLECULAR BIOLOGY REPORTS (2018)

Article Oncology

Targeting tachykinin receptors in neuroblastoma

Anton G. Henssen et al.

ONCOTARGET (2017)

Article Medicine, Research & Experimental

Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma/astrocytoma cells

Keisuke Yamaguchi et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

β-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and G2/M phase transition

Yi-Xin Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Oncology

Cancer and Venous Thromboembolic Disease: A Review

Eoin Donnellan et al.

ONCOLOGIST (2017)

Article Oncology

Antitumor action of temozolomide, ritonavir and aprepitant against human glioma cells

Richard E. Kast et al.

JOURNAL OF NEURO-ONCOLOGY (2016)

Review Oncology

Therapeutic Innovations for Targeting Hepatoblastoma

Agnes Garnier et al.

ANTICANCER RESEARCH (2016)

Article Oncology

Substance P Promotes the Progression of Endometrial Adenocarcinoma

Jing Ma et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2016)

Article Biotechnology & Applied Microbiology

Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance

Prema Robinson et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Article Oncology

Targeting the neurokinin-1 receptor inhibits growth of human colon cancer cells

Agnes Garnier et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

Article Oncology

Targeting the Neurokinin-1 Receptor Compromises Canonical Wnt Signaling in Hepatoblastoma

Matthias Ilmer et al.

MOLECULAR CANCER THERAPEUTICS (2015)

Article Pathology

Role of neurotransmitter Substance P in progression of oral squamous cell carcinoma

Riffat Mehboob et al.

PATHOLOGY RESEARCH AND PRACTICE (2015)

Article Gastroenterology & Hepatology

Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth

Fanyin Meng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

Involvement of substance P and the NK-1 receptor in human pathology

Miguel Munoz et al.

AMINO ACIDS (2014)

Review Medicine, Research & Experimental

Depression as a Risk Factor for Cancer: From Pathophysiological Advances to Treatment Implications

M. Beatriz Currier et al.

ANNUAL REVIEW OF MEDICINE, VOL 65 (2014)

Article Biochemistry & Molecular Biology

Mitochondrial Ca2+ influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction

M-S Hwang et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Oncology

Antitumor activity of neurokinin-1 receptor antagonists in MG-63 human osteosarcoma xenografts

Miguel Munoz et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

Article Neurosciences

EVALUATING THE ROLE OF SUBSTANCE P IN THE GROWTH OF BRAIN TUMORS

E. Harford-Wright et al.

NEUROSCIENCE (2014)

Review Pharmacology & Pharmacy

Safety of neurokinin-1 receptor antagonists

Miguel Munoz et al.

EXPERT OPINION ON DRUG SAFETY (2013)

Article Dentistry, Oral Surgery & Medicine

Expression of proliferative markers in ameloblastomas and malignant odontogenic tumors

D. Otero et al.

ORAL DISEASES (2013)

Review Biochemistry & Molecular Biology

Involvement of substance P and the NK-1 receptor in cancer progression

Miguel Munoz et al.

PEPTIDES (2013)

Review Chemistry, Medicinal

NK-1 receptor antagonists as antitumor drugs: a survey of the literature from 2000 to 2011

Miguel Munoz et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2012)

Article Cell Biology

Targeting of substance P induces cancer cell death and decreases the steady state of EGFR and Her2

Cristina Mayordomo et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2012)

Review Pharmacology & Pharmacy

The NK-1 Receptor: A New Target in Cancer Therapy

Miguel Munoz et al.

CURRENT DRUG TARGETS (2011)

Article Multidisciplinary Sciences

Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer

Earl Gillespie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Radiology, Nuclear Medicine & Medical Imaging

Targeted alpha-radionuclide therapy of functionally critically located gliomas with 213Bi-DOTA-[Thi8,Met(O2)11]-substance P: a pilot trial

D. Cordier et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2010)

Review Oncology

The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug

Miguel Munoz et al.

INVESTIGATIONAL NEW DRUGS (2010)

Editorial Material Hematology

Treatment of acute myeloid leukemia

Elihu H. Estey

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2009)

Article Oncology

Substance P and NK-1R expression in oral precancerous epithelium

M. A. Gonzalez-Moles et al.

ONCOLOGY REPORTS (2009)

Review Cell Biology

Cell motility through plasma membrane blebbing

Oliver T. Fackler et al.

JOURNAL OF CELL BIOLOGY (2008)

Article Immunology

HIF-1α is up-regulated in activated mast cells by a process that involves calcineurin and NFAT

Aurelia Walczak-Drzewiecka et al.

JOURNAL OF IMMUNOLOGY (2008)

Letter Hematology

Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy

A. A. Khorana et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)

Review Nanoscience & Nanotechnology

Nanomedicines in the treatment of emesis during chemotherapy: focus on aprepitant

Ian Olver et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2007)

Review Oncology

Metastasis: a question of life or death

P Mehlen et al.

NATURE REVIEWS CANCER (2006)

Article Hematology

Tachykinins regulate the function of platelets

GJ Graham et al.

BLOOD (2004)

Article Neurosciences

Depression and cancer: Mechanisms and disease progression

D Spiegel et al.

BIOLOGICAL PSYCHIATRY (2003)

Article Multidisciplinary Sciences

Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-κB site on its promoter

S Simeonidis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Biochemistry & Molecular Biology

Substance P

S Harrison et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2001)

Review Gastroenterology & Hepatology

Colon cancer screening

RW Burt

GASTROENTEROLOGY (2000)

Article Pharmacology & Pharmacy

Role of NK1 receptors on cisplatin-induced nephrotoxicity in the rat

AB Alfieri et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2000)