Journal
CANCERS
Volume 12, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/cancers12092351
Keywords
calcium signalling; cancer; cancer hallmarks; TRP channels; CRAC; Orai; STIM; PMCA; SERCA; SPCA; IP3R; cell death; cell proliferation; cell migration; invasion; metastasis
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Funding
- Pancreatic Cancer Research Fund (PCRF) grant
- Medical Research Council (MRC) [MR/P00251X/1]
- MRC [MR/P00251X/1] Funding Source: UKRI
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Cancer is caused by excessive cell proliferation and a propensity to avoid cell death, while the spread of cancer is facilitated by enhanced cellular migration, invasion, and vascularization. Cytosolic Ca(2+)is central to each of these important processes, yet to date, there are no cancer drugs currently being used clinically, and very few undergoing clinical trials, that target the Ca(2+)signalling machinery. The aim of this review is to highlight some of the emerging evidence that targeting key components of the Ca(2+)signalling machinery represents a novel and relatively untapped therapeutic strategy for the treatment of cancer.
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