Mesoporous Si-MCM-41/Polymer as a pH-Responsive Drug Delivery System for Cancer Therapy

Nano-controlled drug delivery systems such as polymer nanocomposites introduce new strategies for the cancer prevention, diagnosis and treatment. In this study, we designed a biocompatible polymer Nanocomposites (NCs) based on modified mobil composition of matter No.41 (MCM-41) nanoparticles (MCM-41-NH2) and copolymer grafted chitosan by acrylamide and acrylic acid (CS-graft-poly (AAm-co-AA) as a pH-sensitive polymer, and employed for targeted anticancer drug delivery. Doxorubicin (DOX) is a potent drug for cancer therapy. DOX was loaded into the synthesized polymer NCs MCM-41-NH2-CS-graft-poly (AAm-co-AA) by formation electrostatic attraction between the positive charge of the DOX and the anionic charge of the poly acrylic acid (PAA), and poly acrylamide (PAAm). Free DOX diffuse rapidly into nucleus, and kill cancerous cells by interaction with deoxyribonucleic acid (DNA). But, keeping active of free anticancer drugs after reaching at the nucleus is difficult due to the bio barriers. Using DOX-loaded into the mentioned polymer NCs can be decreased the toxicity effects (side effects) of DOX on the normal cells and enhance its efficiency on the tumorous cells The release of DOX from the MCM-41-NH2-CS-g-poly (AAm-co-AA) was studied at acidic conditions (on the human breast epithelial adenocarcinoma (MCF-7) cancer cells, pH 5.3 and 40 degrees C). The cytotoxicity of the DOX loaded into MCM-41-NH2-CS-g-poly (AAm-co-AA) on the (MCF-7) cancer cells was evaluated by using MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidefor). The results show that synthetic mesoporous Si-MCM-41/ polymer can act as a targeted drug delivery system for the treatment of MCF-7 cancerous cell.