Journal
CHEMISTRYSELECT
Volume 5, Issue 40, Pages 12398-12406Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202000728
Keywords
Cytotoxicity; Metal-organic Frameworks; Molecular docking study; Rifampicin; Surface area
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Metal Organic Frameworks (MOFs) has been one of the most emerging area of biomedical research. Although MOFs exhibited a wide range of interesting properties, still the drug loading mechanisms by these systems remained unclear. Herein, we have made an attempt to study the uptake capacities of Cu-BTC and MIL-100 (Fe) MOFs towards anti-TB drug Rifampicin (Rif). This work is basically focused to study the effects of structural parameters of MOFs on the loading of the drug Rif. We have synthesized Cu-BTC and MIL-100 (Fe) by adopting a solvent free greener route using a kitchen grinder and thoroughly characterized by using Scanning Electron Microscopy, Powder X-ray Diffraction, Fourier-Transform Infrared Spectroscopy, N-2 adsorption isotherm, Thermo Gravimetric Analysis. In addition to that, we have also studied the cytotoxicity of MOFs as well as binding energy between Cu-BTC and MIL-100 (Fe) with the anti-TB drug Rif. Though MIL-100 (Fe) having high surface area as compared with Cu-BTC but the loading capacity of Cu-BTC is higher than the MIL-100 (Fe). This indicates that the pore volume of MIL-100(Fe) and Cu-BTC plays vital role for the drug loading.
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