Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 22, Issue 12, Pages 1628-1657Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612822666160101123106
Keywords
Biomimetic; dimer; natural product; total synthesis
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Funding
- Engineering and Physical Sciences Research Council [1225401] Funding Source: researchfish
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We present a selection of elegant and diverse biomimetic syntheses of complex natural product dimers. The dimerisation pathways discussed encompass the most prevalent strategies, including: Diels-Alder, Aldol, Mannich, conjugate addition, oxidative, radical and photochemical approaches; each underpinned through rational biosynthetic speculation.
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