Journal
FRONTIERS IN PSYCHIATRY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2020.538683
Keywords
depression; DNA methylation; DNA methyltransferase; neurodevelopment; DNMT3L; DNMT3A; DNMT3B; DNMT1
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Funding
- National Natural Science Foundation of China [81771229]
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Depression is one of the most common psychiatric disorders affecting public health. Studies over the past years suggest that the methylations of some specific genes such asBDNF,SLC6A4, andNR3C1play an important role in the development of depression. Recently, epigenetic evidences suggest that the expression levels of DNA methyltransferases differ in several brain areas including the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens in depression patients and animal models, but the potential link between the expression levels of DNA methylatransferases and the methylations of specific genes needs further investigation to clarify the pathogenesis of depression.
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