Journal
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Volume 17, Issue 8, Pages 741-749Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920101708160517234941
Keywords
microRNAs; miRNA delivery; nanocarriers; lipid-based delivery systems; liposomes; SNALPs; solid lipid nanoparticles; nanoemulsions; drug targeting
Ask authors/readers for more resources
MicroRNAs (miRNAs) are a class of post-transcriptional gene expression modulators. In the past two decades, over 1500 human miRNAs were discovered. These small non-coding RNAs regulate various biological processes, including cell growth, proliferation, differentiation, and cell death. Thus, miRNAs have been proposed as new therapeutical agents in different multifactorial diseases such as cancer. Since miRNAs therapies represent a great promise, many research studies have been focused on the development of delivery strategies to overcome miRNAs biopharmaceutical issues. Lipid delivery systems are undoubtedly the non-viral carriers most largely investigated due to their biocompatibility, biodegradability, easy production, low toxicity and immunogenicity, possibility to easily modify the carriers for targeting strategies. In this mini-review we provide a rapid and updated overview on the lipid delivery system currently used to deliver miRNAs, pointing out the progresses achieved in the optimization of these nanovectors, which led up to the first clinical trial.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available