Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2020.567955
Keywords
insulin-like growth factor; large-for-gestational-age; small-for-gestational-age; insulin; fetuin A
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Funding
- Ministry of Science and Technology of China [2019YFA0802501, 2017YFE0124700]
- National Natural Science Foundation of China [81673178, 81961128023]
- Canadian Institutes of Health Research [158616]
- Shanghai Municipal Health and Family Planning Commission [2020CXJQ01]
- National Human Genetic Resources Sharing Service Platform [2005DKA21300]
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Fetuin-A is a multifunctional glycoprotein that has been implicated in insulin resistance and bone metabolism. We assessed whether fetuin-A is associated with poor or excessive fetal growth. In the Shanghai Birth Cohort, we conducted a nested case-control study of 60 trios of small-for-gestational-age (SGA, birth weight <10th percentile), optimal-for-gestational-age (OGA, 25-75th, the reference) and large-for-gestational-age (LGA, >90th percentile) infants matched by sex and gestational age. Cord plasma concentrations of fetuin-A and fetal growth factors [insulin, proinsulin, insulin-like growth factor (IGF)-I and IGF-II] were measured. Cord plasma fetuin-A concentrations were higher in SGA (809.4 +/- 306.9 mu g/ml,P= 0.026) and LGA (924.2 +/- 375.9 mu g/ml,P< 0.001) relative to OGA (680.7 +/- 262.1 mu g/ml) newborns, and were not correlated to insulin, proinsulin, IGF-I and IGF-II (allP> 0.2). Higher fetuin-A concentrations were associated with increased risks of SGA [OR = 1.67 (1.08-2.58) per SD increment,P= 0.024] and LGA [OR = 2.36 (1.53-3.66),P< 0.001]. Adjusting for maternal and neonatal characteristics and fetal growth factors, the elevated risk changed little for LGA [adjusted OR = 2.28 (1.29-4.01),P= 0.005], but became non-significant for SGA (P= 0.202). Our study is the first to demonstrate that fetuin-A may be involved in excessive fetal growth. This association is independent of fetal growth factors.
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