Journal
CANCER MANAGEMENT AND RESEARCH
Volume 12, Issue -, Pages 7527-7537Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S262745
Keywords
IL-33; cancer; immunity; immune cells
Categories
Funding
- Key Research & Development Plan of Zhejiang Province [2019C04005]
- major national S&T projects for infectious diseases [2018ZX10301401]
- National Key Research and Development Program of China [2018YFC2000500]
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Interleukin (IL)-33 is a member of the IL-1 superfamily and is a crucial cytokine playing the role of a dual-function molecule. IL-33 mediates its function by interacting with its receptor suppression of tumorigenicity 2 (ST2), which is constitutively expressed on T helper (Th)1 cells, Th2 cells, and other immune cells. Previously, we summarized findings on IL-33 and performed an intensive study of the correlation between IL-33 and tumor. IL-33 enables anti-tumor immune responses through Th1 cells and natural killer (NK) cells and plays a role in tumor immune escape in cancers via Th2 cells and regulatory T cells. Herein, we discuss the contradictory role of IL-33 in immune cells in different cancer, and our summaries may be helpful for better understanding of the development of research on IL-33 and tumor immunity.
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