Journal
FRONTIERS IN CHEMISTRY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2020.00800
Keywords
coumarin; fluorescent probe; Cu2+; test strips; bioimaging
Categories
Funding
- National Natural Science Foundation of China [21302019]
- Anhui Provincial Natural Science Foundation [1908085QB78]
- Key Projects of Natural Science Research of Anhui Province Colleges and Universities [KJ2019ZD38]
- Key Projects of Support Program for Outstanding Young Talents in Anhui Province Colleges and Universities [gxyqZD2016068]
- Key Program for Young Talents of Fuyang Normal University [rcxm201902]
- Anhui Province Undergraduate Training Programs for Innovation and Entrepreneurship [S201910371042]
- Horizontal Cooperation Project of Fuyang Municipal Government
- Fuyang Normal University [XDHX201730, XDHX201731]
- Open Project Grant of Key Laboratory of Photochemical Conversion and Optoelectronic Materials, TIPC, Chinese Academy of Sciences [PCOM202002]
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The fluorescent probeL, based on naphthalimide-modified coumarin, was designed, synthesized, and characterized, which could recognize Cu(2+)from other cations selectively and sensitively in HEPES buffer (10 mM, Ph = 7. 4)/CH3CN (1:4, V/V). When the probeLinteracted with Cu2+, the color and the fluorescent intensity changed obviously and it provided the naked-eye detection for Cu2+. The recognition mode between them was achieved by Job's plot, IR, MS, SEM, and(1)HNMR. In addition, test strips made fromLcould still interact with Cu(2+)in tap water effectively. The limit of detection (LOD) ofLwas 3.5 x 10(-6)M. Additionally, the density functional theory (DFT) calculation method was used to analyze the action mechanism ofLtoward Cu2+. Importantly, the fluorescent probeLcould demonstrate favorable selectivity toward Cu(2+)inCaenorhabditis elegans. Thus,Lwas considered to have some potential for application in bioimaging.
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