Journal
CELL SYSTEMS
Volume 12, Issue 1, Pages 23-+Publisher
CELL PRESS
DOI: 10.1016/j.cels.2020.10.003
Keywords
-
Categories
Funding
- National Institutes of Health
- National Human Genome Research Institution [5T32HG002760]
- National Heart Lung and Blood Institute (NHLBI) [K01-HL-130704, 5R01HL-049426]
- National Institute of General Medical Sciences [1R01GM124133]
- National Center for Quantitative Biology of Complex Systems [5P41GM108538]
- Collins Family Foundation Endowment
- Morgridge Institute through a postdoctoral fellowship
Ask authors/readers for more resources
The study conducted RNA-seq and high-resolution mass spectrometry on blood samples from COVID-19-positive and COVID-19-negative patients, identifying molecular features associated with disease severity and outcomes, offering pathophysiological insights and therapeutic suggestions. The observed dysregulation of platelet function, blood coagulation, acute phase response, and endotheliopathy further illuminated the unique COVID-19 phenotype. The findings are presented through a web-based tool enabling interactive exploration and machine learning prediction of COVID-19 severity.
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from COVID-19-positive and COVID-19-negative patients with diverse disease severities and outcomes. Quantified transcripts, proteins, metabolites, and lipids were associated with clinical outcomes in a curated relational database, uniquely enabling systems analysis and cross-ome correlations to molecules and patient prognoses. We mapped 219 molecular features with high significance to COVID-19 status and severity, many of which were involved in complement activation, dysregulated lipid transport, and neutrophil activation. We identified sets of covarying molecules, e.g., protein gelsolin and metabolite citrate or plasmalogens and apolipoproteins, offering pathophysiological insights and therapeutic suggestions. The observed dysregulation of platelet function, blood coagulation, acute phase response, and endotheliopathy further illuminated the unique COVID-19 phenotype. We present a web-based tool (covid-omics.app) enabling interactive exploration of our compendium and illustrate its utility through a machine learning approach for prediction of COVID-19 severity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available