Journal
REDOX BIOLOGY
Volume 36, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.redox.2020.101655
Keywords
Covid-19; Nox-2; NADPH oxidase; Thrombosis
Categories
Funding
- Sapienza University of Rome [RM118164366B89BD]
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Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182) and controls (n = 91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n = 35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.
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