Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 38, Issue -, Pages 44-52Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2016.05.016
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Funding
- BBSRC [BB/L002817/1, BB/K020013/1]
- Wellcome Trust [104960/Z/14/Z]
- Biotechnology and Biological Sciences Research Council [BB/L002817/1, BB/K020013/1] Funding Source: researchfish
- BBSRC [BB/K020013/1, BB/L002817/1] Funding Source: UKRI
- Wellcome Trust [104960/Z/14/Z] Funding Source: Wellcome Trust
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Domains are the functional building blocks of proteins. In this work we discuss how domains can contribute to the evolution of new functions. Domains themselves can evolve through various mechanisms, altering their intrinsic function. Domains can also facilitate functional innovations by combining with other domains to make novel proteins. We discuss the mechanisms by which domain and domain combinations support functional innovations. We highlight interesting examples where changes in domain combination promote changes at the domain level.
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