Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 37, Issue -, Pages 62-70Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.12.003
Keywords
-
Categories
Funding
- Medical Research Council, UK [MC_UP_A025_1011]
- Wellcome Trust New Investigator Award [WT100387]
- EMBO Young Investigator Award
- Medical Research Council [MC_UP_A025_1011] Funding Source: researchfish
- MRC [MC_UP_A025_1011] Funding Source: UKRI
Ask authors/readers for more resources
Recent structures of the dynein motor in three different conformations reveal how it uses ATP hydrolysis to move along microtubules. Attention is now turning to how cytoplasmic dynein-1 and dynactin act together to carry cargos. Cryoelectron microscopy (cryo-EM) has revealed the structure of dynactin and how it binds dynein in the presence of a cargo adaptor protein Bicaudal-D2 (BICD2). Future questions will include how dynein-1 transports so many different cargos and how the 2.4 MDa dynein/dynactin transport machine is regulated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
